Loss of ectodermal competence for lateral line placode formation in the direct developing frog Eleutherodactylus coqui.
Loss of ectodermal competence for lateral line placode formation in the direct developing frog Eleutherodactylus coqui.
复制标题
直接发育的青蛙 Eleutherodactylus coqui 失去形成侧线基板的外胚层能力。
DOI：
10.1006/dbio.1999.9404
复制
发表时间：
1999
影响因子：
2.7
通讯作者：
Northcutt,RG
中科院分区：
文献类型：
--
作者：
Schlosser,G;Kintner,C;Northcutt,RG
在直接发展的青蛙Eleutherodactylus coqui神经瘤和神经节的侧线系统从来没有发展。我们在这里表明，这种侧线系统的情况下，这是进化衍生的无尾类，是由于非常早期的发展变化。外胚层增厚是侧线基板的典型特征，侧线神经母细胞和神经节细胞起源于外胚层增厚。coqui，尽管存在其他神经源性基板。此外，虽然NeuroD在非洲爪蟾的侧线基板中表达，但在E.考基。异源移植实验表明，移植到E. coqui宿主，但E. coquiectoderm在蝾螈宿主上不形成侧线基板。这表明，E. coqui是由于外胚层响应于诱导信号而形成侧线基板的能力的特异性丧失。我们的研究结果（1）表明侧线基板形成的能力是不同的，并与其他神经源性基板的能力和分离（2）支持的想法，侧线系统作为一个模块的发展和进化。
In the direct-developing frog Eleutherodactylus coqui neuromasts and ganglia of the lateral line system never develop. We show here that this absence of the lateral line system, which is evolutionarily derived in anurans, is due to very early changes in development. Ectodermal thickenings, which are typical of lateral line placodes, and from which neuromasts and ganglion cells of the lateral line originate, never form in E. coqui, although other neurogenic placodes are present. Moreover, although NeuroD is expressed in the lateral line placodes of Xenopus laevis, corresponding expression sites are lacking in E. coqui. Heterospecific transplantation experiments show that axolotl ectoderm can be induced to form lateral line placodes after transplantation to E. coqui hosts but that E. coqui ectoderm does not form lateral line placodes on axolotl hosts. This suggests that the loss of the lateral line system in E. coqui is due to the specific loss of ectodermal competence to form lateral line placodes in response to inductive signals. Our results (1) indicate that the competence for lateral line placode formation is distinct and dissociable from the competence to form other neurogenic placodes and (2) support the idea that the lateral line system acts as a module in development and evolution.