Socioeconomic disparities and breast cancer hormone receptor status
Socioeconomic disparities and breast cancer hormone receptor status
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DOI：
10.1007/s10552-012-9966-1
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发表时间：
2012-06-01
影响因子：
2.3
通讯作者：
Zhu, Kangmin
中科院分区：
文献类型：
--
作者：
Andaya, Abegail A.;Enewold, Lindsey;Zhu, Kangmin
最近的研究，虽然不一致，表明社会经济地位（SES）可能与激素受体（HR）状态。本研究的目的是检查SES和乳腺癌HR状态之间的关联内和跨种族/ethnicsgroups分层的诊断时的年龄和肿瘤stage.The研究对象是184，602例女性与事件乳腺癌诊断在2004年至2007年期间，并确定从国家癌症研究所的监测，流行病学和最终结果程序。对数二项回归评估了诊断时居住在高度或中度贫困地区与低度贫困地区的妇女之间的乳腺肿瘤风险，（1）HR阴性与HR阳性，（2）HR未知与HR已知。与富裕地区相比，高度贫困地区的HR阴性肿瘤患病率更高。尽管并不总是显著的，但这在非西班牙裔白色和西班牙裔女性中观察到，而不考虑年龄-肿瘤分期类别，仅在年轻的非西班牙裔黑人女性和非西班牙裔亚洲/太平洋岛民女性中观察到区域和远处分期。与富裕地区相比，高贫困地区的HR未知肿瘤患病率也更高。此外，人力资源状况和贫困水平之间的显着趋势因种族/民族，年龄和肿瘤分期而异。贫困可能与乳腺癌阴性和未知的人力资源状况。这些发现表明非遗传因素对乳腺癌生化特征的影响，并暗示改善低社会经济乳腺癌患者的HR测量或记录具有临床重要性。
Recent research, although inconsistent, indicates that socioeconomic status (SES) may be associated with hormone receptor (HR) status. This study aims to examine the association between SES and breast cancer HR status within and across racial/ethnic groups stratified by age at diagnosis and tumor stage.The study subjects were 184,602 women with incident breast cancer diagnosed during 2004-2007 and identified from the National Cancer Institute's Surveillance, Epidemiology and End Results program. Log-binomial regression assessed the risk of having breast tumors that were (1) HR-negative versus HR-positive and (2) HR-unknown versus HR-known between women who, at the time of diagnosis, were residing in high or medium poverty areas compared to low poverty areas.High poverty areas tended to have a greater prevalence of HR-negative tumors compared to more affluent areas. Although not always significant, this was observed among non-Hispanic white and Hispanic women regardless of age-tumor stage category, and only among young, non-Hispanic black women and non-Hispanic Asian/Pacific Islander women with regional and distant stage. High poverty areas also tended to have a greater prevalence of HR-unknown tumors compared to more affluent areas. Furthermore, significant trends between HR status and poverty level varied by race/ethnicity, age, and tumor stage.Poverty may be related to breast cancer negative and unknown HR status. These findings suggest the effects of non-genetic factors on biochemical features of breast cancer, as well as imply a clinical importance to improve HR measurement or recording for low socioeconomic breast cancer patients.