The dynamic balance of the skin microbiome across the lifespan.
The dynamic balance of the skin microbiome across the lifespan.
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DOI：
10.1042/bst20220216
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发表时间：
2023-02-27
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
几十年来，研究一直集中在确定理想的平衡皮肤微生物群，以预防疾病，并开发治疗方法来促进这种平衡。然而，这种单一的理想平衡可能并不存在。皮肤微生物群在人的一生中会发生变化。这反映在随着年龄的增长，皮肤微生物组的多样性、相互联系的微生物群落的动态变化上。虽然存在核心皮肤微生物分类群，但任何个体的精确群落组成取决于当地皮肤生理学，遗传学，微生物-宿主相互作用以及微生物-微生物相互作用。皮肤表面及其附属物作为人体与环境的关键界面，也在与环境密切接触中不断交换微生物。随着时间的推移，激素波动和免疫系统成熟也会导致皮肤生理上的年龄依赖性变化，从而支持不同的微生物群落结构。在这里，我们回顾了最近对一生中塑造皮肤微生物群的因素的见解。总的来说，这篇综述中总结的工作强调了我们的皮肤如何支持强大的微生物群落，同时仍然保持我们特有的微生物特征，这取决于我们在生命中的位置。这篇综述还将强调这种动态微生物平衡的破坏如何影响皮肤疾病的风险以及影响终身健康。
For decades research has centered on identifying the ideal balanced skin microbiome that prevents disease and on developing therapeutics to foster this balance. However, this single idealized balance may not exist. The skin microbiome changes across the lifespan. This is reflected in the dynamic shifts of the skin microbiome's diverse, inter-connected community of microorganisms with age. While there are core skin microbial taxa, the precise community composition for any individual person is determined by local skin physiology, genetics, microbe–host interactions, and microbe–microbe interactions. As a key interface with the environment, the skin surface and its appendages are also constantly exchanging microbes with close personal contacts and the environment. Hormone fluctuations and immune system maturation also drive age-dependent changes in skin physiology that support different microbial community structures over time. Here, we review recent insights into the factors that shape the skin microbiome throughout life. Collectively, the works summarized within this review highlight how, depending on where we are in lifespan, our skin supports robust microbial communities, while still maintaining microbial features unique to us. This review will also highlight how disruptions to this dynamic microbial balance can influence risk for dermatological diseases as well as impact lifelong health.