COVID-19 pandemic-a focused review for clinicians.
COVID-19 pandemic-a focused review for clinicians.
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DOI：
10.1016/j.cmi.2020.04.023
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发表时间：
2020-07-01
期刊：
影响因子：
--
通讯作者：
Ho, A
中科院分区：
文献类型：
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作者：
Cevik, M;Bamford, C G G;Ho, A
背景：由SARS-CoV-2病毒引起的新冠肺炎大流行仍然是全球卫生、经济和社会的重大问题。自2019年12月出现以来，已经产生了大量的数据，在这个不确定和不断发展的指南和临床实践的时代，临床医生与来自世界各地的这些数据保持同步是至关重要的。目的：这里我们为临床医生提供关于病毒学、诊断、临床表现、病毒脱落、资料来源：我们参考了已发表的关于COVID19及相关方面的同行评议论文和非同行评议的印刷前手稿，重点放在临床管理方面。内容：我们描述了SARS-CoV-2的病毒学特征和新冠肺炎的临床病程，重点是诊断挑战、病毒脱毒持续时间、严重程度标志物和当前的治疗选择。然而，对许多临床医生来说，准确的诊断以及对高危危重病例的早期识别和处理是重要的。为了改进病例管理，需要了解血清学、qRT-PCR和放射学检测的检测概率，以及可用于死亡风险较高的重症病例的现有治疗方案的有效性。
BACKGROUND: The COVID-19 pandemic caused by SARS-CoV-2 remains a significant issue for global health, economics and society. A wealth of data has been generated since its emergence in December 2019, and it is vital for clinicians to keep up with this data from across the world at a time of uncertainty and constantly evolving guidelines and clinical practice.OBJECTIVES: Here we provide an update for clinicians on the recent developments in the virology, diagnostics, clinical presentation, viral shedding, and treatment options for COVID-19 based on current literature.SOURCES: We considered published peer-reviewed papers and non-peer-reviewed pre-print manuscripts on COVID19 and related aspects with an emphasis on clinical management aspects.CONTENT: We describe the virological characteristics of SARS-CoV-2 and the clinical course of COVID-19 with an emphasis on diagnostic challenges, duration of viral shedding, severity markers and current treatment options.IMPLICATIONS: The key challenge in managing COVID-19 remains patient density. However, accurate diagnosis as well as early identification and management of high-risk severe cases are important for many clinicians. For improved management of cases, there is a need to understand test probability of serology, qRT-PCR and radiological testing, and the efficacy of available treatment options that could be used in severe cases with a high risk of mortality.