Changes in regulation of human zinc metabolism with age.
Changes in regulation of human zinc metabolism with age.
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人体锌代谢调节随年龄的变化。
DOI：
10.1152/ajpregu.1992.263.5.r1162
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Henkin,RI
中科院分区：
文献类型：
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作者：
Wastney,ME;Ahmed,S;Henkin,RI
为了评估锌代谢随年龄的变化，对20-84岁的健康成人(男26人，女21人)口服或静脉注射65锌后进行了动力学研究。研究涵盖了连续两个9个月的时期，受试者每天的基础饮食摄入量约为10毫克锌，同时每天额外口服100毫克锌。使用来自血浆、红细胞、尿液、粪便、肝脏、大腿和全身的数据通过隔室分析来分析锌的代谢[M.E.Wastney，R.L.Aamodt，W.F.Rumble和R.I.Henkin]。上午好。J.Physiol.251(监管综合薪酬物理。20)：R398-R408,1986]。锌代谢观察值和模型计算值随年龄的变化通过回归分析进行评估。在基础状态下，红细胞中锌的释放量随年龄增长而减少。在锌负荷过程中，血浆锌浓度、尿锌排泄和肝脏锌的反应(定义为基础状态的变化)随年龄增加而增加，而红细胞锌摄取分数的反应随年龄增加而降低。男性对锌摄入量的反应随着年龄的增长而增加，而女性对内源性锌排出分数的反应随着年龄的增长而降低。四种随年龄变化的反应(尿液排泄、红细胞交换、吸收和内源性排泄)发生在预先确定的锌代谢调节部位。结果表明，锌代谢的调节随着年龄的增长而变化。
To assess changes in zinc metabolism with age, kinetic studies were performed in healthy adults (26 men, 21 women) aged 20-84 yr after a single oral or intravenous bolus of 65Zn. Studies covered two consecutive 9-mo periods while subjects were on a basal dietary intake of approximately 10 mg Zn/day and while taking an additional 100 mg Zn/day orally. Zinc metabolism was analyzed by compartmental analysis using data from plasma, red blood cells, urine, feces, liver, thigh, and whole body [M. E. Wastney, R. L. Aamodt, W. F. Rumble, and R. I. Henkin. Am. J. Physiol. 251 (Regulatory Integrative Comp. Physiol. 20): R398-R408, 1986]. Changes in observed and model calculated values of zinc metabolism were assessed on age by regression. During basal state, zinc release from red blood cells decreased with age. During zinc loading, response (defined as change from basal state) of plasma zinc concentration, urinary zinc excretion, and liver zinc increased with age, while response of fraction of zinc taken up by red blood cells decreased with age. In men, response of amount of zinc absorbed increased with age and in women response of fraction of endogenous zinc excreted decreased with age. Four responses that changed with age (urinary excretion, red blood cell exchange, absorption, and endogenous excretion) occurred at previously defined sites of regulation of zinc metabolism. Results show that regulation of zinc metabolism changes with age.