Safety of thrombolytic therapy for acute ischemic stroke after recent transient ischemic attack.
Safety of thrombolytic therapy for acute ischemic stroke after recent transient ischemic attack.
复制标题
近期短暂性脑缺血发作后急性缺血性卒中溶栓治疗的安全性。
DOI：
10.1016/j.jstrokecerebrovasdis.2010.12.008
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Cucchiara,BrettL
中科院分区：
文献类型：
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作者：
McKinney,JamesS;Masjuan,Jaime;Purroy,Francisco;Calvet,David;Ay,Hakan;Cucchiara,BrettL
本研究的目的是评估近期短暂性脑缺血发作（TIA）后接受溶栓治疗的急性缺血性卒中（AIS）患者的症状性脑出血（SICH）发生率。共发现23例。TIA和AIS之间的中位时间间隔为9小时。AIS时美国国立卫生研究院卒中量表评分的中位数为12。卒中发作和溶栓治疗之间的中位时间间隔为90分钟。溶栓治疗包括IV溶栓（70%）、IA溶栓（17%）、IA和机械溶栓（9%）以及IV后IA和机械溶栓（4%）。本组溶栓后SICH发生率为8.6%（2/23）。
BACKGROUNDThe objective of this study was to assess the rate of symptomatic intracerebral hemorrhage (SICH) in patients given thrombolytic therapy for acute ischemic stroke (AIS) after recent transient ischemic attack (TIA).METHODSThis was a multicenter study of patients with confirmed TIA within 7 days before an AIS that was treated with intravenous (IV), intra-arterial (IA), or mechanical thrombolysis. A total of 23 cases were identified.RESULTSThe median time interval between index TIA and AIS was 9 hours. The median National Institutes of Health Stroke Scale score at the time of AIS was 12. The median time interval between stroke onset and thrombolytic treatment was 90 minutes. Thrombolytic therapies included IV thrombolysis (70%), IA thrombolysis (17%), IA and mechanical thrombolysis (9%), and IV followed by IA and mechanical thrombolysis (4%). The rate of postthrombolysis SICH in this group was 8.6% (2/23).CONCLUSIONSThe rate of SICH in our cohort appears similar to overall postthrombolysis hemorrhage rates.