128-channel EEG source imaging in epilepsy: Clinical yield and localization precision
128-channel EEG source imaging in epilepsy: Clinical yield and localization precision
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DOI：
10.1097/00004691-200403000-00001
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发表时间：
2004-03-01
影响因子：
2.4
通讯作者：
Seeck, M
中科院分区：
文献类型：
--
作者：
Michel, CM;Lantz, G;Seeck, M
作者评价了发作间期癫痫活动的高分辨率EEG源成像的可行性、临床产率和定位精度。一个连续的系列44例顽固性癫痫的各种原因，谁进行了全面的术前癫痫评估，进行了128通道脑电图记录。一个标准化的源成像程序限制到个人的灰质被应用到平均尖峰的每个病人。在32名患者中，术前检查发现了局灶性致癫痫区域。128通道EEG源成像正确定位在这些患者中的30个（93.7%）的该区域。定位不精确的原因是记录和分析程序的简化，这是为了速度和标准化而被接受的。在24例接受手术的患者中，通过计算源最大值到切除区域的距离来评估128通道EEG源成像的亚叶精度。该分析显示19例（79%）为零距离。作者得出结论，高分辨率发作间期EEG源成像是一种有价值的非侵入性功能神经成像技术。该技术的速度，易用性，灵活性和低成本保证了其在临床实践中的使用。
The authors evaluated the feasibility, clinical yield, and localization precision of high-resolution EEG source imaging of interictal epileptic activity. A consecutive series of 44 patients with intractable epilepsy of various causes, who underwent a comprehensive presurgical epilepsy evaluation, were subjected to a 128-channel EEG recording. A standardized source imaging procedure constrained to the individual gray matter was applied to the averaged spikes of each patient. In 32 patients, the presurgical workup identified a focal epileptogenic area. The 128-channel EEG source imaging correctly localized this area in 30 of these patients (93.7%). Imprecise localization was explained by simplifications of the recordings and analysis procedure, which was accepted for the benefit of speed and standardization. In a subgroup of 24 patients who underwent operations, the sublobar precision of the 128-channel EEG source imaging was evaluated by calculating the distance of the source maximum to the resected area. This analysis revealed zero distance in 19 cases (79%). The authors conclude that high-resolution interictal EEG source imaging is a valuable noninvasive functional neuroimaging technique. The speed, ease, flexibility, and low cost of this technique warrant its use in clinical practice.