Quadriceps fatigue after cycle exercise in patients with COPD compared with healthy control subjects
Quadriceps fatigue after cycle exercise in patients with COPD compared with healthy control subjects
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DOI：
10.1378/chest.123.4.1104
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发表时间：
2003-04-01
期刊：
影响因子：
9.6
通讯作者：
Kufel, TJ
中科院分区：
文献类型：
--
作者：
Mador, MJ;Bozkanat, E;Kufel, TJ
研究目的：COPD患者在力竭性循环运动后可发生股四头肌疲劳。本研究的目的是确定COPD患者与匹配的对照组相比，自行车运动引起的疲劳程度是否更大。主题：9名男性COPD患者的平均（+/- SE）年龄为66 +/- 3岁，平均FEV 1值为1.31 +/- 0.15 L和36 +/- 5%预测值进行了比较，9名健康男性受试者的平均年龄为66 +/- 2 years.Methods：COPD患者行使60%的峰值工作能力，直到筋疲力尽。健康的老年受试者在恒定负荷运动期间，以产生与COPD患者相似的绝对摄氧量（（V）/dotO（2））的负荷进行运动。通过测量周期运动前后的抽搐力（非增强抽搐力[TwQu]和增强抽搐力[TwQp]）检测股四头肌疲劳。结果：COPD患者运动平均持续时间为8.4 ± 1.8 min。运动期间超过dotO（2）的V为预测值的50 ± 6%。健康的老年对照受试者运动10分钟，产生的a（V）超过dotO（2）的48 +/- 1%预测值。运动后COPD患者的TwQu显著下降，但在匹配的对照受试者中没有。两组运动后TwQp均显著下降，但COPD患者运动后TwQp下降幅度显著更大。结论：对于dotO（2）和周期运动持续时间相同的绝对值（V），COPD患者的疲劳程度显著高于年龄匹配的健康对照组。
Study objectives: Quadriceps fatigue can occur in patients with COPD after exhaustive cycle exercise. The purpose of this study was to determine whether the degree of fatigue elicited by cycle exercise was greater in patients with COPD compared with matched control subjects. Subjects: Nine male patients with COPD with a mean (+/- SE) age of 66 +/- 3 years and mean FEV1 values of 1.31 +/- 0.15 L and 36 +/- 5% predicted were compared to nine healthy male subjects with a mean age of 66 +/- 2 years.Methods: Patients with COPD exercised at 60% of peak work capacity until exhaustion. Healthy elderly subjects exercised at a workload that was chosen to produce a similar absolute oxygen uptake ((V)over dotO(2)) during constant-load exercise as that obtained by the patients with COPD. Quadriceps fatigue was detected by measuring twitch force (unpotentiated twitch force [TwQu] and potentiated twitch force [TwQp]) before and after cycle exercise.Results: Patients with COPD exercised for a mean duration of 8.4 +/- 1.8 min. (V)over dotO(2) during exercise was 50 +/- 6% of predicted. The healthy elderly control subjects exercised for 10 min, generating a (V)over dotO(2) of 48 +/- 1% predicted. TwQu fell significantly postexercise in the patients with COPD but not in the matched control subjects. TwQp fell significantly postexercise in both groups, but the fall in TwQp postexercise was significantly greater in the patients with COPD.Conclusion: For the same absolute (V)over dotO(2) and duration of cycle exercise, the amount of fatigue elicited was significantly greater in the patients with COPD compared to age-matched healthy control subjects.