Bismuth nitrate pentahydrate-induced novel nitration of eugenol.
Bismuth nitrate pentahydrate-induced novel nitration of eugenol.
复制标题
DOI：
10.1186/2191-2858-1-9
复制
发表时间：
2011-09-20
期刊：
影响因子：
--
通讯作者：
Banik, Bimal K
中科院分区：
文献类型：
--
作者：
Canales, Luis;Bandyopadhyay, Debasish;Banik, Bimal K
背景：丁香酚是丁香油的主要成分，具有多种药用活性。为了增强其药性，需要对其结构进行修饰。另一方面，五水硝酸铋已被确定为几种有机化合物的优良的生态友好型硝化剂。结果：研究了五水合硝酸铋对丁香酚的硝化作用。研究了25种不同的情况。确定微波诱导无溶剂反应为最佳反应条件。结论：光谱分析证实5-硝基丁香酚是所有病例的唯一产物。未检测到氧化或异构化产物。
BACKGROUND: Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhance the medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate has been established as an excellent eco-friendly nitrating agent for several classes of organic compounds.RESULTS: Bismuth nitrate pentahydrate-induced nitration of eugenol has been investigated very thoroughly. Twenty five different conditions have been studied. The microwave-induced solvent-free reaction has been identified as the best condition.CONCLUSIONS: Spectral analyses confirm that 5-nitroeugenol is the sole product in all the cases. No oxidized or isomerized product could be detected.