An appeal for a more evidence based approach to biopesticide safety in the EU.
An appeal for a more evidence based approach to biopesticide safety in the EU.
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DOI：
10.1093/femsec/fix169
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发表时间：
2018
影响因子：
4.2
通讯作者：
B. Raymond;B. Federici
中科院分区：
文献类型：
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作者：
B. Raymond;B. Federici
EFSA回应了我们关于安全使用昆虫病原体Bt的观点文章。在这样做时，他们承认没有直接证据表明B。苏云金杆菌可引起腹泻。尽管如此，他们仍然继续重申不能将Bt与蜡状芽孢杆菌区分开来的主张，尽管几乎所有Bt菌株，当然还有所有生物农药菌株，都可以与B区分开来。蜡样芽胞杆菌多位点测序分型。欧洲食品安全局还继续重复未经证实的推测性假设，即Bt菌株可能导致人类隐性感染。这一假设与所有可用的安全性和流行病学数据的重要性大相径庭。此外，还建立了B.蜡状菌群的临床感染也表明，生物农药菌株从未与人类感染有关。我们的立场是，Bt生物农药和Bt分离物从无脊椎动物病原体占主导地位的分支是不能引起人类感染，是由国际社会的科学家熟悉的数据，在农业和林业中广泛使用了四十多年的Bt的安全性得到了很好的支持。
EFSA responded to our perspective article on the safe use of the insect pathogen Bacillus thrurigiensis (Bt). In doing so they admitted that there is no direct evidence to suggest that B. thuringiensis can cause diarrhoea. They nevertheless continue to repeat the assertion that Bt cannot be distinguished from Bacillus cereus, even though nearly all Bt strains, and certainly all biopesticide strains, can be distinguished from B. cereus using multi-locus sequencing typing. EFSA also continue to repeat the unsupported and speculative hypothesis that Bt strains could be capable of causing cryptic infections in humans. This hypothesis is very much against the weight of all available safety and epidemiological data. Moreover, genotyping schemes of B. cereus group clinical infections also show that biopesticide strains have never been associated with human infections. Our position that Bt biopesticides and Bt isolates from the clade dominated by invertebrate pathogens are incapable of causing infections in humans is well supported by the international community of scientists familiar with the data on the safety of Bt after more than four decades of extensive use in agriculture and forestry.