Human papillomavirus infection and risk of lung cancer in never-smokers and women: an 'adaptive' meta-analysis.
Human papillomavirus infection and risk of lung cancer in never-smokers and women: an 'adaptive' meta-analysis.
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DOI：
10.4178/epih/e2015052
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发表时间：
2015
影响因子：
3.8
通讯作者：
Kim EH
中科院分区：
文献类型：
--
作者：
Bae JM;Kim EH
韩国人肺癌的发病率在女性和从不吸烟的男性和女性中都在增加。人乳头瘤病毒(HPV)感染已被认为是非吸烟者和妇女(LCNSW)患肺癌的一个可改变的危险因素。这项系统性综述(SR)旨在评估HPV感染与LCNSW肺癌风险之间的关系。根据先前的SR和一些专家评论，我们使用PubMed和Scope数据库确定了被引用、被引用或相关的文章。选择所有报告LCNSW中HPV感染的优势比的病例对照研究。计算具有95%可信区间(CI)的汇总优势比(SOR)。共纳入四项病例对照研究。由于同质性(i平方=0.0%)，采用固定效应模型。女性和不吸烟者的OR值分别为5.32(95%CI，1.75~16.17)和4.78(2.25~10.15)。这些结果表明HPV感染在LCNSW中有显著的作用。显然，制定一项预防LCNSW的计划可能是必要的。
The incidence of lung cancer in Koreans is increasing in women and in both men and women with a never-smoking history. Human papillomavirus (HPV) infection has been suggested as a modifiable risk factor of lung cancer in never-smokers and women (LCNSW). This systematic review (SR) aimed to evaluate an association between HPV infection and lung cancer risk in LCNSW. Based on a prior SR and some expert reviews, we identified refereed, cited, or related articles using the PubMed and Scopus databases. All case-control studies that reported the odds ratio of HPV infection in LCNSW were selected. An estimate of the summary odds ratio (SOR) with 95% confidence intervals (CI) was calculated. A total of four case-control studies were included. The fixed-effect model was applied because of homogeneity (I-squared=0.0%). The SORs in women and in never-smokers were 5.32 (95% CI, 1.75 to 16.17) and 4.78 (2.25 to 10.15) respectively. These results showed a significant effect of HPV infection in LCNSW. It is evident that developing a preventive plan against LCNSW may be necessary.