Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
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DOI：
10.1073/pnas.0705667104
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发表时间：
2007-07-31
影响因子：
11.1
通讯作者：
Hanson, Mark A.
中科院分区：
文献类型：
--
作者：
Gluckman, Peter D.;Lillycrop, Karen A.;Hanson, Mark A.
对环境线索的发育可塑性可以表现为多型性，如某些昆虫的离散变体，或表现为明显连续的表型谱，如大多数哺乳动物的性状。成年大鼠的代谢表型，包括肥胖倾向，高胰岛素血症，和食欲过盛，显示可塑性在产前营养和新生儿管理的脂肪因子瘦素。在这里，我们报告说，新生儿瘦素对肝脏基因表达和成年后的表观遗传状态的影响是定向依赖于动物在子宫内的营养状况。这些结果表明，在哺乳动物的发展过程中，一个线索的反应的方向可以由以前暴露于另一个，这表明环境诱导的表型的不连续分布的潜力，类似于现象的多型性。
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for most mammalian traits. The metabolic phenotype of adult rats, including the propensity to obesity, hyperinsulinemia, and hyperphagia, shows plasticity in response to prenatal nutrition and to neonatal administration of the adipokine leptin. Here, we report that the effects of neonatal leptin on hepatic gene expression and epigenetic status in adulthood are directionally dependent on the animal's nutritional status in utero. These results demonstrate that, during mammalian development, the direction of the response to one cue can be determined by previous exposure to another, suggesting the potential for a discontinuous distribution of environmentally induced phenotypes, analogous to the phenomenon of polyphenism.