Second primary neoplasms in patients with retinoblastoma.
Second primary neoplasms in patients with retinoblastoma.
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视网膜母细胞瘤患者的第二原发肿瘤。
DOI：
10.1038/bjc.1986.110
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发表时间：
1986-05
影响因子：
8.8
通讯作者：
Kingston JE
中科院分区：
文献类型：
--
作者：
Draper GJ;Sanders BM;Kingston JE
在一系列 882 名视网膜母细胞瘤患者中，其中 384 名已知患有该疾病的遗传形式，另外 498 名患者中，30 名患者出现了第二原发性肿瘤。这些第二种肿瘤的范围与视网膜母细胞瘤的治疗形式有关。整个系列中第二个肿瘤的累积发病率在诊断后12年为2.0%，在18年后为4.2%。对于遗传性视网膜母细胞瘤患者，18 年后所有第二种肿瘤的累积发病率为 8.4%，单独骨肉瘤的累积发病率为 6.0%。排除所有可能的治疗影响，遗传性视网膜母细胞瘤幸存者在 18 年后罹患骨肉瘤的固有风险估计为 2.2%。在放射治疗领域，18 年后所有第二肿瘤的累积发病率为 6.6%，仅骨肉瘤为 3.7%。有一些证据表明，遗传性视网膜母细胞瘤患者对辐射的致癌作用特别敏感。结果还表明，使用环磷酰胺可能会增加遗传性视网膜母细胞瘤患者发生第二原发肿瘤的风险。这里报道的视网膜母细胞瘤幸存者中第二原发肿瘤的发病率低于之前发表的系列中引用的发病率。这篇论文和其他论文的证据强烈表明视网膜母细胞瘤和恶性黑色素瘤之间存在关联。
In a series of 882 retinoblastoma patients, 384 known to have the genetic form of the disease and 498 others, 30 patients developed second primary neoplasms. The spectrum of these second neoplasms is discussed in relation to the forms of treatment used for the retinoblastoma. Cumulative incidence rates of second tumours in the whole series are 2.0% at 12 years after diagnosis and 4.2% after 18 years. For patients with the genetic form of retinoblastoma the cumulative incidence rate after 18 years is 8.4% for all second neoplasms and 6.0% for osteosarcomas alone. The inherent risk among survivors from genetic retinoblastoma of developing an osteosarcoma, excluding all possible effects of treatment, is estimated to be 2.2% after 18 years. Within the field of radiation treatment the cumulative incidence rate for all second neoplasms after 18 years is 6.6% and for osteosarcomas alone 3.7%. There is some evidence that patients with genetic retinoblastoma are particularly sensitive to the carcinogenic effects of radiation. The results also suggest that the use of cyclophosphamide may increase the risk of second primary neoplasms in patients with genetic retinoblastoma. The incidence rates of second primary neoplasms in retinoblastoma survivors reported here are lower than those quoted for previously published series. Evidence from this and other papers strongly suggests an association between retinoblastoma and malignant melanoma.