Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues
Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues
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对人类、黑猩猩、猕猴和小鼠组织的大规模分析揭示了脑脂质组的组织和进化
DOI：
10.1016/j.neuron.2015.01.003
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发表时间：
2015-02-18
期刊：
影响因子：
16.2
通讯作者：
Khaitovich, Philipp
中科院分区：
文献类型：
--
作者：
Bozek, Katarzyna;Wei, Yuning;Khaitovich, Philipp
脂质是神经系统的重要组成部分。在这里，我们对人类、黑猩猩、恒河猴和小鼠的三个大脑区域以及肾脏和骨骼肌的脂质成分进行了大规模的质谱分析。人脑显示出最独特的脂质成分：在我们的研究中检查的 5,713 种脂质化合物中，76% 在人脑中要么富集，要么贫乏。与非神经组织的脂质特征相比，灵长类动物大脑中富含的脂质浓度水平的演变速度大约是非神经组织脂质特征的四倍，并且在人类新皮质区域（但在小脑中）显示出进一步加速的变化。人类特异性浓度变化得到相应酶的人类特异性表达变化的支持。这些结果首次揭示了脂质在人类大脑进化中的作用。
Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76% of 5,713 lipid compounds examined in our study are either enriched or depleted in the human brain. Concentration levels of lipids enriched in the brain evolve approximately four times faster among primates compared with lipids characteristic of non-neural tissues and show further acceleration of change in human neocortical regions but not in the cerebellum. Human-specific concentration changes are supported by human-specific expression changes for corresponding enzymes. These results provide the first insights into the role of lipids in human brain evolution.