Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors.
Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors.
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作者：
Cui A;Ding D;Li Y
肝脏是调节全身代谢稳态并控制肝细胞增殖和生长的主要代谢器官。转录因子ATF/CREB家族整合营养和生长信号以调节肝脏中的代谢和细胞生长，并且失调的ATF/CREB家族信号传导与2型糖尿病、非酒精性脂肪肝疾病和癌症的进展有关。本文就ATF/CREB家族在糖脂代谢和细胞生长调节中的作用及其在肝脏生理中的重要性作一综述。我们还强调了如何破坏ATF/CREB网络有助于人类疾病，并讨论了在临床上治疗靶向ATF/CREB成员的观点。
The liver is a major metabolic organ that regulates the whole-body metabolic homeostasis and controls hepatocyte proliferation and growth. The ATF/CREB family of transcription factors integrates nutritional and growth signals to the regulation of metabolism and cell growth in the liver, and deregulated ATF/CREB family signaling is implicated in the progression of type 2 diabetes, nonalcoholic fatty liver disease, and cancer. This article focuses on the roles of the ATF/CREB family in the regulation of glucose and lipid metabolism and cell growth and its importance in liver physiology. We also highlight how the disrupted ATF/CREB network contributes to human diseases and discuss the perspectives of therapeutically targeting ATF/CREB members in the clinic.
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