Gender differences in symptomatic profiles of depression: Results from the Sao Paulo Megacity Mental Health Survey
Gender differences in symptomatic profiles of depression: Results from the Sao Paulo Megacity Mental Health Survey
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DOI：
10.1016/j.jad.2012.11.041
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发表时间：
2013-05-01
影响因子：
6.6
通讯作者：
Andrade, Laura Helena
中科院分区：
文献类型：
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作者：
Alexandrino-Silva, Clovis;Wang, Yuan-Pang;Andrade, Laura Helena
背景资料：很少有研究调查抑郁症的症状亚型及其相关的gender.Methods：数据来自圣保罗大城市心理健康调查。1207名受试者（864名女性; 343名男性）的症状配置文件的基础上的症状最严重的抑郁发作的一生进行了检查，通过潜在的类分析。结果：对于男性和女性，3类模型是最好的解决方案。在两种性别中均发现轻度分类（女性41.1%;男性40.1%）。性别差异出现在最有症状的班级。在女性中，它们被标记为非典型（39.3%）和非典型（19.5%），在躯体/植物性症状中彼此不同。非典型类表现为抑制和进食/睡眠症状减少，而非典型类食欲/体重增加和嗜睡。对于男性来说，区分两种最具症状的类型的症状与精神运动活动有关：忧郁症/精神运动性迟缓（40.4%）和激动性抑郁症（19.6%）。最高的类间比例的激动和赛车的想法被发现之间的男性在激动类，与类似的双极混合状态。局限性：分析仅限于那些谁赞同的问题，他们最严重的一生抑郁发作;标准化的评估，由外行面试官;小男性样本量。结论：目前的抑郁症分类结构在症状水平上是异质的，可以识别出性别不同的亚型。这些症状特征对抑郁症的疾病分类学和治疗学具有潜在的意义。(C)2012 Elsevier B. V.保留所有权利。
Background: Few studies have investigated symptomatic subtypes of depression and their correlates by gender.Methods: Data are from the Sao Paulo Megacity Mental Health Survey. Symptom profiles of 1207 subjects (864 women; 343 men) based upon symptoms of the worst depressive episode in lifetime were examined through latent class analysis. Correlates of gender-specific latent classes were analyzed by logistic regression.Results: For both men and women, a 3-class model was the best solution. A mild class was found in both genders (41.1% in women; 40.1% in men). Gender differences appeared in the most symptomatic classes. In women, they were labeled melancholic (39.3%) and atypical (19.5%), differing among each other in somatic/vegetative symptoms. The melancholic class presented inhibition and eating/sleeping symptoms in the direction of decreasing, whereas the atypical class had increased appetite/weight, and hypersomnia. For men, symptoms that differentiate the two most symptomatic classes were related to psychomotor activity: a melancholic/psychomotor retarded (40.4%) and agitated depression (19.6%). The highest between-class proportion of agitation and racing thoughts was found among men in the agitated class, with similarity to bipolar mixed state.Limitations: Analyses were restricted to those who endorsed questions about their worst lifetime depressive episode; the standardized assessment by lay interviewers; the small male sample size.Conclusions: The construct of depression of current classifications is heterogeneous at the symptom level, where gender different subtypes can be identified. These symptom profiles have potential implications for the nosology and the therapeutics of depression. (C) 2012 Elsevier B.V. All rights reserved.