Metabolic and behavioral characteristics of metabolically obese but normal-weight women
Metabolic and behavioral characteristics of metabolically obese but normal-weight women
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DOI：
10.1210/jc.2004-0265
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发表时间：
2004-10-01
影响因子：
5.8
通讯作者：
Poehlman, ET
中科院分区：
文献类型：
--
作者：
Conus, F;Allison, DB;Poehlman, ET
一个独特的个体子集被称为代谢肥胖但体重正常（MONW）。尽管这些年轻女性年龄小，体重指数正常，但她们患代谢综合征的风险可能会增加。我们试图确定代谢和行为因素，这些因素可能会将MONW女性与正常代谢状况的年轻女性区分开来。根据胰岛素敏感性的临界值（由体内平衡模型评估估计），96名妇女被分为MONW （n = 12）或非MONW （n = 84）。各组之间潜在的区分表型包括血清脂质、胃促生长素、瘦素、脂联素、身体组成和体脂分布、静息和体力活动能量消耗、峰值摄氧量、饮食摄入、饮食行为、家族史和生活方式变量。尽管两组之间的身体质量指数相似，但与非MONW女性相比，MONW女性表现出更高的体脂率、更低的无脂质量、更低的体力活动能量消耗和更低的峰值摄氧量。MONW妇女的血浆胆固醇水平较高，而其他血脂、胃饥饿素、瘦素、脂联素和静息能量消耗没有差异。MONW妇女的饮食限制评分低于非MONW妇女，但在去抑制、饥饿和饮食摄入量方面没有差异。对所有受试者进行逐步回归分析显示，体内平衡模型评估中33.5%的独特方差可以用体脂百分比（17.1%）、饮食限制水平（10.4%）和年龄（6%）变量来解释。代谢和饮食行为变量都有助于MONW妇女有害的代谢谱。他们表现出较低的胰岛素敏感性，可能是由于久坐的行为模式导致了他们的高肥胖。此外，对食物的认知态度（即饮食限制）和伴随的生活方式行为可能在调节MONW妇女的胰岛素敏感性中发挥作用。
A 'unique subset of individuals termed metabolically obese but normal weight (MONW) has been identified. These young women are potentially at increased risk for development of the metabolic syndrome despite their young age and normal body mass index. We seek to determine metabolic and behavioral factors that could potentially distinguish MONW women from young women with a normal metabolic profile.Ninety-six women were classified as MONW ( n = 12) or non-MONW ( n = 84) based on a cut point of insulin sensitivity ( as estimated by the homeostasis model assessment). Potentially distinguishing phenotypes between groups measured included serum lipids, ghrelin, leptin, adiponectin, body composition and body fat distribution, resting and physical activity energy expenditure, peak oxygen uptake, dietary intake, dietary behavior, and family history and lifestyle variables.Despite a similar body mass index between groups, MONW women showed higher percent body fat, lower fat-free mass, lower physical activity energy expenditure, and lower peak oxygen uptake than non-MONW women. Plasma cholesterol level was higher in MONW women, whereas no differences were noted for other blood lipids, ghrelin, leptin, adiponectin, and resting energy expenditure. MONW women had lower dietary restraint scores than non-MONW women, but no differences were noted in disinhibition, hunger, and dietary intake. Stepwise regression analysis performed on all subjects showed that 33.5% of the unique variance of the homeostasis model assessment was explained with the variables of percentage of body fat (17.1%), level of dietary restraint (10.4%), and age (6%).Both metabolic and dietary behavioral variables contribute to the deleterious metabolic profile of MONW women. They display lower insulin sensitivity due potentially to a cluster of sedentary behavior patterns that contribute to their higher adiposity. Furthermore, cognitive attitudes toward food (i.e. dietary restraint) and concomitant lifestyle behaviors may play a role in regulating insulin sensitivity in MONW women.