Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics.
Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics.
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DOI：
10.1007/s00198-016-3614-7
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Kazakia G
中科院分区：
文献类型：
--
作者：
Heilmeier U;Cheng K;Pasco C;Parrish R;Nirody J;Patsch JM;Zhang CA;Joseph GB;Burghardt AJ;Schwartz AV;Link TM;Kazakia G
我们研究了绝经后2型糖尿病（T2 D）女性皮质骨孔隙的特征和空间分布。脆性骨折的T2 D受试者中皮质和骨膜层的高孔隙率表明，这些皮质区可能特别容易受到T2 D诱导的毒性的影响，并可能反映皮质微血管病变。皮质骨孔隙率升高被认为是T2 D患者骨骼脆性高的主要原因之一。然而，到目前为止，尚不清楚糖尿病皮质多孔性是否是由血管皮质改变或骨髓空间扩张引起的。在此，我们使用一种新的皮质层分析技术，研究了有脆性骨折病史的T2 D组（DMFx，指定为高风险组）和无脆性骨折的T2 D组（DM，指定为低风险组）的皮质孔特征和空间径向分布，并将其结果与有（Fx）和无脆性骨折（Co）的非糖尿病对照组进行比较。80名绝经后女性（n = 20/组）接受了胫骨远端和桡骨的高分辨率外周定量计算机断层扫描（HR-pQCT）。皮质骨分为三层，包括骨内膜，皮质中层和骨膜层的宽度相等。在每层内，计算总孔面积（TPA）、总孔数（TPN）和平均孔面积（阿帕）。统计分析采用Mann-Whitney检验和ANOVA与事后检验。与DM组相比，DMFx受试者的总体孔隙率升高了+90至+365%（p=0.001）。皮质层分析显示，这种增加的孔隙度是为两个骨骼网站局限于中皮质层，其次是骨膜层（皮质中部+1327%TPA，p≤0.001，骨膜+634%TPA，p=0.002），并且在分层和骨骼部位与高TPN相关（+430%TPN，p<0.001）和高阿帕（阿帕，p<0.001）。高风险T2 D组中皮质中层和骨膜层的高孔隙率表明，这些皮质区可能特别容易受到T2 D诱导的毒性的影响，并可能反映皮质微血管病变。
We investigated the characteristics and spatial distribution of cortical bone pores in postmenopausal women with type 2 diabetes (T2D). High porosity in the midcortical and periosteal layers in T2D subjects with fragility fractures suggests that these cortical zones might be particularly susceptible to T2D-induced toxicity and may reflect cortical microangiopathy. Elevated cortical porosity is regarded as one of the main contributors to the high skeletal fragility in T2D. However, to date, it remains unclear if diabetic cortical porosity results from vascular cortical changes or from an expansion in bone marrow space. Here, we used a novel cortical laminar analysis technique to investigate the characteristics and spatial radial distribution of cortical pores in a T2D group with prior history of fragility fractures (DMFx, assigned high-risk group) and a fracture-free T2D group (DM, assigned low-risk group) and to compare their results to non-diabetic controls with (Fx) and without fragility fractures (Co). Eighty postmenopausal women (n = 20/group) underwent high-resolution peripheral quantitative computed tomography (HR-pQCT) of the distal tibia and radius. Cortical bone was divided into three layers of equal width including an endosteal, midcortical, and periosteal layer. Within each layer, total pore area (TPA), total pore number (TPN), and average pore area (APA) were calculated. Statistical analysis employed Mann-Whitney tests and ANOVA with post hoc tests. Compared to the DM group, DMFx subjects exhibited +90 to +365 % elevated global porosity (p=0.001). Cortical laminar analysis revealed that this increased porosity was for both skeletal sites confined to the midcortical layer, followed by the periosteal layer (midcortical +1327 % TPA, p≤0.001, periosteal +634 % TPA, p=0.002), and was associated in both layers and skeletal sites with high TPN (+430 % TPN, p<0.001) and high APA (+71.5 % APA, p<0.001). High porosity in the midcortical and periosteal layers in the high-risk T2D group suggests that these cortical zones might be particularly susceptible to T2D-induced toxicity and may reflect cortical microangiopathy.
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影响因子：
4.1
作者：
Dong, X. Neil;Qin, An;Xu, Jiake;Wang, Xiaodu
通讯作者：
Wang, Xiaodu
影响因子：
4.1
作者：
Alikhani, Mani;Alikhani, Zoubin;Graves, Dana T.
通讯作者：
Graves, Dana T.
影响因子：
6.2
作者：
Khosla, S;Riggs, BL;Melton, LJ
通讯作者：
Melton, LJ
影响因子：
5.8
作者：
Boutroy, S;Bouxsein, ML;Delmas, PD
通讯作者：
Delmas, PD
DOI：
10.1016/j.msec.2005.08.021
发表时间：
2006-09-01
期刊：
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
影响因子：
--
作者：
Nalla, R. K.;Kruzic, J. J.;Ritchie, R. O.
通讯作者：
Ritchie, R. O.