Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys
Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys
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DOI：
10.1097/00008877-200403000-00007
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发表时间：
2004-03-01
影响因子：
1.6
通讯作者：
Winger, G
中科院分区：
文献类型：
--
作者：
Fantegrossi, WE;Woods, JH;Winger, G
相对较少的研究评估了致幻化合物的增强作用，并且没有此类研究试图在具有包括血清素介导的增强作用经验的行为史的动物中产生这些化合物的偶然反应。本研究的目的是调查几种致幻化合物对具有 3,4-亚甲基二氧基甲基苯丙胺 (MDMA) 自我给药史的恒河猴维持自我给药行为的能力，并比较两种结构类别（吲哚烷基胺和苯基异丙胺）的一系列药物剂量的这些效果。结果表明，没有化合物产生可靠的反应，并且没有受试者以高于临时盐水产生的速率自行施用 4-碘-2,5-二甲氧基苯基异丙胺 (DOI)。然而，四分之三的受试者在一次或多次使用 N,N-二甲基色胺 (DMT)、麦司卡林或赛洛西宾的治疗中确实以 0.75 至 3.0 响应/秒的速率做出响应。在其中一些维持自我给药的疗程中，动物获得了所有可用输液的大部分，并在疗程结束时表现出陶醉的状态。这种短暂的自我给药模式可能表明这些化合物具有弱的增强作用，或混合的增强和厌恶作用。
Relatively few studies have assessed the reinforcing effects of hallucinogenic compounds, and no such studies have attempted to engender contingent responding for these compounds in animals with behavioral histories that include experience with serotonergically mediated reinforcing effects. The objectives of the present study were to investigate the capacity of several hallucinogenic compounds to maintain self-administration behavior in rhesus monkeys with a previous history of 3,4-methylene-d ioxymethampheta mine (MDMA) self-administration, and to compare these effects across a range of doses of drugs from two structural classes (indolealkylamines and phenylisopropylamines). The results indicate that no compound generated reliable responding and that no subject ever self-administered 4-iodo-2,5-dimethoxyphenylisopropylamine (DOI) at rates above those engendered by contingent saline. However, 3 out of 4 subjects did respond at rates between 0.75 and 3.0 responses/s in one or more sessions where N,N-dimethyltryptamine (DMT), mescaline or psilocybin were available. During some of these sessions in which self-administration was maintained, animals earned a majority of all available infusions and appeared intoxicated by the end of the session. This pattern of transient self-administration may indicate that these compounds have weak reinforcing effects, or mixed reinforcing and aversive effects.