A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation.
A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation.
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DOI：
10.3389/fcvm.2021.716938
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发表时间：
2021
影响因子：
3.6
通讯作者：
Dave G
中科院分区：
文献类型：
--
作者：
Stoner L;Barone Gibbs B;Meyer ML;Fryer S;Credeur D;Paterson C;Stone K;Hanson ED;Kowalsky RJ;Horiuchi M;Mack CP;Dave G
久坐行为，特别是坐着，在许多当代社会中无处不在。这是一个主要的社会问题，因为有证据表明坐姿行为与心血管疾病的发病率和死亡率之间存在密切联系。毫不奇怪，领先的公共卫生机构已经开始倡导“减少”坐着的行为。然而，这些指导方针通常是模糊和不具体的。缺乏关于长时间坐着的具体指南是由于缺乏促进制定指南的可用证据。为了告知政策，需要设计良好的随机对照试验来测试特定和可翻译的坐姿减少策略的有效性。为了指导随机对照试验的设计，这篇综述假设，首先需要填补文献中的几个空白。在对坐姿行为对当代社会的重要性进行一般性讨论之后，讨论了以下每一项：（i）急性坐姿暴露和系统生理学;（ii）系统生理学工具箱的建议;（iii）急性坐姿暴露的研究设计考虑;以及（iv）以坐姿为重点的研究的翻译。
Sedentary behavior, particularly sitting, is ubiquitous in many contemporary societies. This is a major societal concern considering the evidence for a strong association between sitting behavior and cardiovascular disease morbidity and mortality. Unsurprisingly, leading public health agencies have begun to advocate “reduction” in sitting behavior. Though, the guidelines are typically vague and non-specific. The lack of specific guidelines for prolonged sitting is attributable to the absence of available evidence to facilitate guideline development. To inform policy, well-designed randomized controlled trials are required to test the efficacy of specific and translatable sitting reduction strategies. To guide the design of randomized controlled trials, this review postulates that several gaps in the literature first need to be filled. Following a general discussion of the importance of sitting behavior to contemporary societies, each of the following are discussed: (i) acute sitting exposure and systems physiology; (ii) recommendations for a systems physiology toolbox; (iii) study design considerations for acute sitting exposure; and (iv) translation of sitting-focused research.