Anxiety and error-related brain activity
Anxiety and error-related brain activity
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DOI：
10.1016/s0301-0511(03)00103-0
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发表时间：
2003-10-01
影响因子：
2.6
通讯作者：
Simons, RF
中科院分区：
文献类型：
--
作者：
Hajcak, G;McDonald, N;Simons, RF
错误相关负性（ERN/Ne）是与监测动作和检测错误相关的事件相关脑电位（ERP）的一个组成部分。这是一个急剧的负偏转，通常发生在50至150毫秒后的反应执行，并已与前扣带皮层（ACC）的活动。在强迫症（OCD）患者中观察到增强的ERN-反映了被假设为OCD病理生理学的一部分的异常ACC活性。我们最近报道，ERN在一组具有OC特征的大学生中也得到了增强。本研究通过测量在宾夕法尼亚州立大学焦虑问卷（PSWQ）或Snake（SNAQ）和Spider（SPQ）量表的组合版本中得分较高的大学生的ERN来扩展这些发现。结果表明，像OC科目，科目谁得分高的一般焦虑和担心的措施，增强了错误相关的大脑活动相对于恐惧和非焦虑的控制对象。增强的ERN被发现在焦虑谱系障碍中超越了强迫症，但在这些障碍中也显示出一些特异性。(C)2003 Elsevier B. V.保留所有权利。
Error-related negativity (ERN/Ne) is a component of the event-related brain potential (ERP) associated with monitoring action and detecting errors. It is a sharp negative deflection that generally occurs from 50 to 150 ms following response execution and has been associated with anterior cingulate cortex (ACC) activity. An enhanced ERN has been observed in patients with obsessive-compulsive disorder (OCD)-reflecting abnormal ACC activity hypothesized as part of the pathophysiology of OCD. We recently reported that the ERN is also enhanced in a group of college students with OC characteristics. The present study extended these findings by measuring the ERN in college undergraduates who scored high on either the Penn State Worry Questionnaire (PSWQ) or a combined version of the Snake (SNAQ) and Spider (SPQ) Questionnaires. Results indicate that, like OC subjects, subjects who score high on a measure of general anxiety and worry have enhanced error-related brain activity relative to both phobic and non-anxious control subjects. The enhanced ERN was found to generalize beyond OCD within the anxiety spectrum disorders but also shows some specificity within these disorders. (C) 2003 Elsevier B.V. All rights reserved.