Current Opinion on Molecular Characterization for GBM Classification in Guiding Clinical Diagnosis, Prognosis, and Therapy.

Current Opinion on Molecular Characterization for GBM Classification in Guiding Clinical Diagnosis, Prognosis, and Therapy.
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GBM 分类的分子特征指导临床诊断、预后和治疗的当前观点

DOI:
10.3389/fmolb.2020.562798
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发表时间:
2020
影响因子:
5
通讯作者:
Dong L
Dong L
中科院分区:
生物学3区
文献类型:
--
作者:
Zhang P;Xia Q;Liu L;Li S;Dong L

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胶质母细胞瘤(GBM)是高度侵袭性的,也是成人中最致命的脑肿瘤。其特征在于肿瘤间和肿瘤内的异质性,患者生存期短,缺乏有效的治疗。预后和治疗选择由来自基因转录、遗传改变和DNA甲基化的分子数据驱动。四种GBM分子亚型是前神经型、神经型、经典型和间质型。更有效的个性化治疗在很大程度上取决于更高分辨率的分子亚型特征,结合基因治疗,免疫治疗和类器官技术。在这篇综述中,我们总结了指导诊断、预后和治疗建议的主要GBM分子分类。
Glioblastoma (GBM) is highly invasive and the deadliest brain tumor in adults. It is characterized by inter-tumor and intra-tumor heterogeneity, short patient survival, and lack of effective treatment. Prognosis and therapy selection is driven by molecular data from gene transcription, genetic alterations and DNA methylation. The four GBM molecular subtypes are proneural, neural, classical, and mesenchymal. More effective personalized therapy heavily depends on higher resolution molecular subtype signatures, combined with gene therapy, immunotherapy and organoid technology. In this review, we summarize the principal GBM molecular classifications that guide diagnosis, prognosis, and therapeutic recommendations.
DOI: 10.7150/ijms.11047
发表时间: 2015
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