Coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia
Coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia
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DOI：
10.1016/s0008-6363(01)00347-9
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发表时间：
2001-09-01
影响因子：
10.8
通讯作者：
Lerman, A
中科院分区：
文献类型：
--
作者：
Herrmann, J;Lerman, LO;Lerman, A
目的：实验性高胆固醇血症与血管新生血管有关，在初始病变形成之前或之后未知发生。因此，本研究旨在确定冠状动脉血管新生与内皮功能障碍（早期动脉粥样硬化的标志）的时间进程。研究方法：雌性家猪饲喂正常饮食（第1组）、高胆固醇血症饮食2周和4周（第2组）或高胆固醇血症饮食6周和12周（第3组）。在体外分析舒张反应缓激肽作为指标的心外膜内皮功能。冠状动脉血管的空间格局和密度的三维显微计算机断层扫描进行了评估。结果如下：第1组（93 ± 6%）和第2组（89 ± 7%）的冠状动脉对缓激肽的舒张反应正常，但第3组（71 ± 11%; P
Objective: Experimental hypercholesterolemia is associated with vasa vasorum neovascularization, unknown to occur before or after initial lesion formation. Thus, this study was performed to determine the temporal course of neovascularization of coronary vasa vasorum in relation to endothelial dysfunction, a hallmark of early atherosclerosis. Methods: Female domestic pigs were fed a normal diet (Group 1), a hypercholesterolemic diet for 2 and 4 weeks (Group 2), or a hypercholesterolemic diet for 6 and 12 weeks (Group 3). In vitro analysis of relaxation response to bradykinin served as an index for epicardial endothelial function. Spatial pattern and density of coronary vasa vasorum were assessed by three-dimensional microscopic computed tomography. Results: Relaxation response of coronary arteries to bradykinin was normal in both Group 1 (93 +/-6%) and Group 2 (89 +/-7%) but impaired in Group 3 (71 +/- 11%; P