Driver mutations in melanoma: lessons learned from bench-to-bedside studies.
Driver mutations in melanoma: lessons learned from bench-to-bedside studies.
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DOI：
10.1007/s11912-012-0249-5
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发表时间：
2012-10
影响因子：
4.7
通讯作者：
Kluger, Harriet M.
中科院分区：
文献类型：
--
作者：
Mehnert, Janice M.;Kluger, Harriet M.
人类样本中体细胞驱动突变的鉴定允许开发黑素瘤的分子分类。转移性黑色素瘤治疗的最新突破是由于对该疾病的分子生物学的这些重要的新见解，特别是激活BRAFV600E突变的抑制剂的开发。在这篇文章中，已知参与黑素细胞恶性转化的几种突变的作用进行了审查，包括BRAF，PTEN，NRAS，ckit和p16以及一些新出现的突变在皮肤和葡萄膜黑色素瘤。总结了导致这些发现的工作台到床边合作，并讨论了针对特定患者亚群中驱动突变的潜在治疗策略。
The identification of somatic driver mutations in human samples has allowed for the development of a molecular classification for melanoma. Recent breakthroughs in the treatment of metastatic melanoma have arisen as a result of these significant new insights into the molecular biology of the disease, particularly the development of inhibitors of activating BRAFV600E mutations. In this article the roles of several mutations known to be involved in the malignant transformation of melanocytes are reviewed including BRAF, PTEN, NRAS, ckit, and p16 as well as some of the emerging mutations in cutaneous and uveal melanoma. The bench to bedside collaborations that resulted in these discoveries are summarized, and potential therapeutic strategies to target driver mutations in specific patient subsets are discussed.
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影响因子：
8.8
作者：
Davies, M. A.;Stemke-Hale, K.;Tellez, C.;Calderone, T. L.;Deng, W.;Prieto, V. G.;Lazar, A. J. F.;Gershenwald, J. E.;Mills, G. B.
通讯作者：
Mills, G. B.
影响因子：
64.8
作者：
Bertolotto, Corine;Lesueur, Fabienne;Bressac-de Paillerets, Brigitte
通讯作者：
Bressac-de Paillerets, Brigitte
影响因子：
4.3
作者：
Cronin JC;Wunderlich J;Loftus SK;Prickett TD;Wei X;Ridd K;Vemula S;Burrell AS;Agrawal NS;Lin JC;Banister CE;Buckhaults P;Rosenberg SA;Bastian BC;Pavan WJ;Samuels Y
通讯作者：
Samuels Y
DOI：
10.1158/1078-0432.ccr-10-2276
发表时间：
2011-01-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Ellerhorst JA;Greene VR;Ekmekcioglu S;Warneke CL;Johnson MM;Cooke CP;Wang LE;Prieto VG;Gershenwald JE;Wei Q;Grimm EA
通讯作者：
Grimm EA
影响因子：
6.5
作者：
Akslen, LA;Angelini, S;Kumar, R
通讯作者：
Kumar, R