Di-2-methoxyethyl azodicarboxylate (DMEAD): An inexpensive and separation-friendly alternative reagent for the Mitsunobu reaction
Di-2-methoxyethyl azodicarboxylate (DMEAD): An inexpensive and separation-friendly alternative reagent for the Mitsunobu reaction
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DOI：
10.1246/cl.2007.566
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发表时间：
2007-04-05
影响因子：
1.6
通讯作者：
Hagiya, Kazutake
中科院分区：
文献类型：
--
作者：
Sugimura, Takashi;Hagiya, Kazutake
偶氮二甲酸二-2-甲氧基乙酯（DMEAD）被制备作为用于Mitsunobu反应的DEAD或DIAD的替代物。由于DMEAD的极性和水溶性，从DMEAD产生的肼二羧酸的去除变得更加容易。
Di-2-methoxyethyl azodicarboxylate (DMEAD) was prepared as an alternative of DEAD or DIAD for the Mitsunobu reaction. Removal of the hydrazinedicarboxylate generated from DMEAD becomes much easier owing to the polar and water-soluble property.