Increase in Adiponectin Level Prevents the Development of Type 2 Diabetes in Japanese Men With Low Adiponectin Levels.
Increase in Adiponectin Level Prevents the Development of Type 2 Diabetes in Japanese Men With Low Adiponectin Levels.
复制标题
DOI：
10.1210/js.2018-00033
复制
发表时间：
2018-07-01
影响因子：
4.1
通讯作者：
Matsuzawa Y
中科院分区：
文献类型：
--
作者：
Kashiwagi R;Yamada Y;Ito Y;Mitsui Y;Sakaue T;Iwamoto R;Saisho K;Tamba S;Yamamoto K;Watanabe T;Fujimoto T;Iwahashi H;Matsuzawa Y
低血清脂联素(Ad)水平是2型糖尿病(T2 DM)发生的重要危险因素。目的：探讨基线血清AD水平较低的受试者的AD变化是否能降低T2 DM的发生。我们对2007年4月至2015年5月在住友医院体检中心进行了两次以上全身健康检查的7052名健康日本男性进行了一项大规模的纵向研究。根据基线广告水平，参与者被分成四分位数组。最低基线Ad组(≤5.2μg/mL)的受试者根据Ad(%ΔAd)的百分比变化分为四分位数亚组，并根据终点Ad(>；5.2和≤5.2μg/mL)分为两个亚组。T2 DM的累积发病率。最低基线AD组(≤5.2μg/mL)的T2 DM累积发病率显著高于其他四分位数组。≥Ad值最大(21.5%)和次大(9.3%~21.4%)的ΔAd增高组T2 DM累积发病率显著低于%ΔAd增高组(P<；0.001和P=0.005)。终点Ad>；5.2μg/mL亚组的T2 DM累积发病率显著低于≤5.2μg/mL亚组(P<；0.001)。增加至少~10%或-gt；5.2μg/ml的血清Ad水平，可以潜在地降低低基线Ad水平的日本男性患T2 DM的风险，他们是T2 DM的高危人群。在基线血清Ad水平较低的日本男性中，增加∼10%或>；5.2μg/mL的血清Ad水平可以降低发生T2 DM的风险。
Low serum adiponectin (Ad) level is an important risk factor for the development of type 2 diabetes mellitus (T2DM). To determine whether the changes in Ad in subjects with low baseline serum Ad levels can reduce the rate of development of T2DM. We performed a large-scale longitudinal study of 7052 healthy Japanese men who underwent general health checkups more than twice between April 2007 and May 2015 at the Physical Check up Center, Sumitomo Hospital. The participants were divided into quartile groups according to baseline Ad level. Subjects of the lowest baseline Ad group (≤5.2 μg/mL) were subdivided into quartile subgroups according to the percent change in Ad (%ΔAd) and into two subgroups according to endpoint Ad (>5.2 and ≤5.2 μg/mL). The cumulative incidence rate of T2DM. The cumulative incidence rate of T2DM of the lowest baseline Ad group (≤5.2 μg/mL) was significantly higher than the other quartile groups. The cumulative incidence rates of T2DM were significantly lower in the largest (≥21.5%) and the second largest (9.3% to 21.4%) %ΔAd-increased subgroups compared with the %ΔAd-decreased subgroup (P < 0.001 and P = 0.005, respectively). The cumulative incidence rates of T2DM were significantly lower in the endpoint Ad >5.2 μg/mL subgroup than in the ≤5.2 μg/mL subgroup (P < 0.001). Increases in serum Ad levels of at least ~10% or >5.2 μg/mL can potentially reduce the risk of development of T2DM in Japanese men with low baseline Ad levels who are at a high risk of developing T2DM. Increases in serum Ad levels of ∼10% or >5.2 μg/mL in Japanese men with low baseline serum Ad levels can reduce the risk of development of T2DM.