Onchocerciasis-associated epilepsy: From recent epidemiological and clinical findings to policy implications.
Onchocerciasis-associated epilepsy: From recent epidemiological and clinical findings to policy implications.
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DOI：
10.1002/epi4.12054
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发表时间：
2017-06
期刊：
影响因子：
3
通讯作者：
Idro R
中科院分区：
文献类型：
--
作者：
Colebunders R;Njamnshi AK;van Oijen M;Mukendi D;Kashama JM;Mandro M;Gumisiriza N;Preux PM;Suykerbuyk P;Idro R
据报道，在许多盘尾丝虫病流行地区，癫痫的患病率很高。在本文中，我们讨论了盘尾丝虫病相关癫痫（OAE）最近的流行病学和临床方面以及公共卫生影响，并提出了减轻疾病负担的策略。OAE可能表现为多种临床表现，包括点头综合征和Nakalanga综合征。然而，最常见的临床表现是全身性（主要是强直性阵挛性）癫痫发作。OAE的一个特征是发病年龄在3岁至18岁之间，并聚集在黑蝇出没湍急的河流附近的某些家庭和村庄。通过增加伊维菌素（CDTi）社区定向治疗的地理和治疗覆盖率，将积极监测癫痫与抗癫痫药物早期治疗和预防盘尾丝虫病相结合的策略可能会大大减轻疾病负担。
A high prevalence of epilepsy is reported in many onchocerciasis‐endemic regions. In this paper we discuss recent epidemiological and clinical aspects as well as public health implications of onchocerciasis‐associated epilepsy (OAE) and propose a strategy to reduce the burden of disease. OAE probably presents in a variety of clinical manifestations, including the nodding syndrome and the Nakalanga syndrome. The most common clinical presentation, however, is generalized (primarily tonic‐clonic) seizures. A characteristic of OAE is the onset of seizures between the ages of 3 and 18 years and clustering in certain families and villages close to rapid‐flowing black‐fly‐infested rivers. A strategy combining active surveillance for epilepsy with early treatment with antiepileptic drugs and prevention of onchocerciasis by increasing the geographical and therapeutic coverage of community‐directed treatment with ivermectin (CDTi) may considerably decrease the burden of disease.