Actions of peptides isolated from amphibian skin on amylase release from dispersed pancreatic acini.
Actions of peptides isolated from amphibian skin on amylase release from dispersed pancreatic acini.
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从两栖动物皮肤中分离出的肽对分散的胰腺腺泡中淀粉酶释放的作用。
DOI：
10.1152/ajpendo.1979.236.5.e571
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
J. Gardner
中科院分区：
文献类型：
--
作者：
E. R. Uhlemann;A. Rottman;J. Gardner
在分散的腺泡制备豚鼠胰腺，从两栖动物皮肤（雨蛙肽，铃蟾肽，litorin，和physalaemin）以及eledoisin，从后唾液腺分离的一种肽的地中海节肢动物，引起了显着增加淀粉酶的释放。每种两栖动物肽增强由血管活性肠肽或促胰液素引起的淀粉酶释放的刺激，因为由两栖动物肽加上血管活性肠肽或促胰液素引起的淀粉酶释放的增加显著大于由每种促分泌素单独作用引起的增加的总和。两栖动物肽加胆囊收缩素或卡巴胆碱没有增强淀粉酶分泌。
In dispersed acini prepared from guinea pig pancreas, peptides isolated from amphibian skin (caerulein, bombesin, litorin, and physalaemin) as well as eledoisin, a peptide isolated from the posterior salivary gland of a Mediterranean octopod, caused a significant increase in amylase release. Each amphibian peptide potentiated the stimulation of amylase release caused by vasoactive intestinal peptide or secretin in that the increase in amylase release caused by an amphibian peptide plus vasoactive intestinal peptide or secretin was significantly greater than the sum of the increase caused by each secretagogue acting alone. Potentiation of amylase secretion did not occur with an amphibian peptide plus cholecystokinin or carbachol.