Depression in multiple sclerosis: Relationship to planning ability
Depression in multiple sclerosis: Relationship to planning ability
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DOI：
10.1017/s1355617701766027
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发表时间：
2001-09-01
影响因子：
2.6
通讯作者：
Randolph, JJ
中科院分区：
文献类型：
--
作者：
Arnett, PA;Higginson, CI;Randolph, JJ
最近的研究表明，多发性硬化症（MS）患者在涉及计划的努力执行任务方面存在缺陷。鉴于MS中抑郁症的高患病率以及抑郁症与执行任务表现之间的普遍报道，MS中的计划障碍可能与抑郁症有关。我们比较了抑郁症和非抑郁症MS患者在规划任务（伦敦塔TOL）的表现，以评估这一假设。与非抑郁症MS患者相比，抑郁症MS患者在TOL上进行了显著（p <0.05）更多的移动，每次试验花费的时间更多。进行了随访回归分析，包括TOL和加速注意力/工作记忆任务指数，发现与作者先前报告中MS的抑郁症相关。该分析显示，抑郁评分的25%的方差是由最敏感的加速注意力/工作记忆任务预测的。此外，该方差与TOL时间/试验指数预测的方差完全重叠。唯一明显非加速的任务指数，每次试验的TOL移动，与预测MS抑郁评分的独特方差（8%）相关。这些结果表明，减缓信息处理速度，其次，缺乏nonspeeded中央执行技能，可能是核心的认知功能障碍的抑郁症患者的特点。
Recent research has demonstrated deficits on effortful executive tasks involving planning in multiple sclerosis (MS) patients. Given the high prevalence of depression in MS and the commonly reported link between depression and performance on executive tasks, planning impairments in MS may be associated with depression. We compared the performance of depressed and nondepressed MS patients on a planning task (Tower of London-TOL) to evaluate this hypothesis. Compared with nondepressed MS patients, depressed MS patients made significantly (p < .05) more moves and took more time per trial on the TOL. A follow-up regression analysis was conducted that included the TOL and speeded attentional/working memory task indices found to be associated with depression in MS from the authors' prior reports. This analysis revealed that 25% of the variance in depression scores was predicted by the most sensitive speeded attentional/working memory task. Furthermore, this variance overlapped completely with variance predicted by the TOL-time/trial index. The only clearly nonspeeded task index, TOL-moves per trial, was associated with unique variance (8%) in predicting MS depression scores. These results suggest that slowed information processing speed and, secondarily, deficient nonspeeded central executive skill, may be core to the cognitive deficits characteristic of depressed MS patients.