Embryonic Schwann cell development: the biology of Schwann cell precursors and early Schwann cells
Embryonic Schwann cell development: the biology of Schwann cell precursors and early Schwann cells
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DOI：
10.1046/j.1469-7580.1997.19140501.x
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发表时间：
1997-11-01
影响因子：
2.4
通讯作者：
Mirsky, R
中科院分区：
文献类型：
--
作者：
Jessen, KR;Mirsky, R
导致神经嵴生成雪旺细胞的细胞事件最近得到了澄清，现在有可能勾勒出大鼠和小鼠雪旺细胞谱系的相对简单的模型。神经嵴细胞必须经历三个主要的发育转变才能成为成熟的雪旺细胞。这些是由嵴细胞形成的雪旺细胞前体，由前体形成的未成熟雪旺细胞，最后是出生后和可逆的非髓磷脂和髓磷脂形成的雪旺细胞。涉及神经调节因子的轴突信号是这些事件的重要调节因子，特别是雪旺细胞前体的存活、增殖和分化。
The cellular events leading to the generation of Schwann cells from the neural crest have recently been clarified and it is now possible to outline a relatively simple model of the Schwann cell lineage in the rat and mouse. Neural crest cells have to undergo 3 main developmental transitions to become mature Schwann cells. These are the formation of Schwann cell precursors from crest cells, the formation of immature Schwann cells from precursors and, lastly, the postnatal and reversible generation of non-myelin-and myelin-forming Schwann cells. Axonal signals involving neuregulins are important regulators of these events, in particular of the survival, proliferation and differentiation of Schwann cell precursors.