Discoidin domain receptors guide axons along longitudinal tracts in C. elegans.
Discoidin domain receptors guide axons along longitudinal tracts in C. elegans.
复制标题
线虫中的盘状结构域受体沿着纵向束引导轴突。
DOI：
10.1016/j.ydbio.2012.11.001
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发表时间：
2013
影响因子：
2.7
通讯作者：
H. Hutter
中科院分区：
文献类型：
--
作者：
Thomas Unsoeld;Ja;H. Hutter
Discoidin domain receptors are a family of receptor tyrosine kinases activated by collagens. Here we characterize the role of the two discoidin domain receptors, ddr-1 and ddr-2, of the nematode C. elegans during nervous system development. ddr-2 mutant animals exhibit axon guidance defects in major longitudinal tracts most prominently in the ventral nerve cord. ddr-1 mutants show no significant phenotype on their own but significantly enhance guidance defects of ddr-2 in double mutants. ddr-1 and ddr-2 GFP-reporter constructs are expressed in neurons with axons in all affected nerve tracts. DDR-1 and DDR-2 GFP fusion proteins localize to axons. DDR-2 is required cell-autonomously in the PVPR neuron for the guidance of the PVPR pioneer axon, which establishes the left ventral nerve cord tract and serves as substrate for later outgrowing follower axons. Our results provide the first insight on discoidin domain receptor function in invertebrates and establish a novel role for discoidin domain receptors in axon navigation and axon tract formation.
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影响因子：
10.5
作者：
Bhatt, RS;Tomoda, T;Hatten, ME
通讯作者：
Hatten, ME
影响因子：
3.3
作者：
Kang, SH;Kramer, JM
通讯作者：
Kramer, JM
DOI：
10.1101/sqb.2003.68.159
发表时间：
2003-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
McKay, SJ;Johnsen, R;Moerman, DG
通讯作者：
Moerman, DG
细胞相互作用控制秀丽隐杆线虫 HSN 轴突的生长、分支和束束方向。
DOI：
10.1242/dev.117.3.1071
发表时间：
1993
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Garriga,G;Desai,C;Horvitz,HR
通讯作者：
Horvitz,HR
影响因子：
11.4
作者：
MELLO, CC;KRAMER, JM;AMBROS, V
通讯作者：
AMBROS, V