Predictors of Mortality and Outcomes of Therapy in Low-Flow Severe Aortic Stenosis: A Placement of Aortic Transcatheter Valves (PARTNER) Trial Analysis
Predictors of Mortality and Outcomes of Therapy in Low-Flow Severe Aortic Stenosis: A Placement of Aortic Transcatheter Valves (PARTNER) Trial Analysis
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DOI：
10.1161/circulationaha.112.001290
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发表时间：
2013-06-11
期刊：
影响因子：
37.8
通讯作者：
Leon, Martin B.
中科院分区：
文献类型：
--
作者：
Herrmann, Howard C.;Pibarot, Philippe;Leon, Martin B.
背景-低流量（LF）严重主动脉瓣狭窄患者的预后和治疗存在争议。方法和结果-主动脉经导管瓣膜置入（PARTNER）试验将严重主动脉瓣狭窄患者随机分为药物治疗组与经导管主动脉瓣置换术（TAVR;不可手术队列）和外科主动脉瓣置换术与TAVR（高危队列）。在971例可评价超声心动图的患者中（92%），LF（每搏输出量指数）
Background- The prognosis and treatment of patients with low-flow (LF) severe aortic stenosis are controversial.Methods and Results- The Placement of Aortic Transcatheter Valves (PARTNER) trial randomized patients with severe aortic stenosis to medical management versus transcatheter aortic valve replacement (TAVR; inoperable cohort) and surgical aortic valve replacement versus TAVR (high-risk cohort). Among 971 patients with evaluable echocardiograms (92%), LF (stroke volume index