IVF: a short but exciting story.
IVF: a short but exciting story.
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IVF：一个简短但令人兴奋的故事。
DOI：
10.1097/gco.0000000000000178
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发表时间：
2015
影响因子：
2.1
通讯作者：
Seli,Emre
中科院分区：
文献类型：
--
作者：
GarciaVelasco,JuanAntonio;Seli,Emre
罗伯特·G·爱德华兹博士和帕特里克·斯特普托博士开启了医学的新纪元，他们成功地使人类卵子受精，在培养皿中短暂培养，并将其移植到妇女的子宫中生下了孩子。这一革命性的成就使数百万不育夫妇怀孕，妇女即使到了更年期也能生孩子。爱德华兹博士因开发试管受精技术于2010年被授予诺贝尔奖，而1988年去世的斯特普托博士没有分享诺贝尔奖，因为这些奖项不是在死后颁发的。与许多科学先驱一样，爱德华兹博士和斯特普托博士取得了他们所做的成就，尽管存在质疑和许多直言不讳的批评者，其中一些人认为‘试管婴儿’的想法是不道德的。由于得不到政府的财政支持，这两名调查人员依靠私人资金，在英国曼彻斯特郊外一家小医院的一个小实验室里进行了实验。1978年7月25日，他们在那里产下了世界上第一个试管受精婴儿路易丝·布朗。在第一个通过试管受孕的婴儿出生后不久，爱德华兹博士再次观察到胚胎生长得更快更有可能怀孕[2]。后来出现了控制性超排卵(COH)的概念，以在每个周期产生一个以上的卵子[3]，随后是胚胎[4]和卵母细胞[5]冷冻保存，植入前遗传学诊断[6，7]，以及用于克服受精缺陷的胞浆内单精子注射[8]。
Dr Robert G. Edwards and Dr Patrick Steptoe opened a new era in medicine when they successfully fertilized a human egg, grew it briefly in a petri dish and transferred it into a woman’s uterus to produce a baby [1]. This revolutionary achievement enabled millions of infertile couples to conceive and women to have babies even after reaching menopause. Dr Edwards was awarded the Nobel Prize in 2010 for the development of IVF, while Dr Steptoe, who died in 1988, did not receive a share of the Nobel, as the prizes are not awarded posthumously. Similar to many pioneers of science, Dr Edwards and Dr Steptoe achieved what they did despite a skeptical establishment and many vocal critics, some of whom believed that the idea of a ‘test tube baby’was immoral. Denied financial support from the government, the two investigators relied on private financing, and conducted their experiments in a tiny laboratory at a small hospital outside Manchester, United Kingdom. It was there that they delivered the world’s first IVF baby, Louise Brown, on 25 July 1978.Soon after the birth of the first baby conceived through IVF, it was again Dr Edwards who observed that embryos that grow faster were more likely to result in a pregnancy [2]. Later came the concepts of controlled ovarian hyperstimulation (COH) to generate more than one egg per cycle [3], followed by embryo [4] and oocyte [5] cryopreservation, preimplantation genetic diagnosis [6, 7], and intracytoplasmic sperm injection to overcome fertilization defects [8].