Serum levels of soluble interleukin-2 receptor alpha (slL-2Rα) as a predictor of outcome in brucellosis
Serum levels of soluble interleukin-2 receptor alpha (slL-2Rα) as a predictor of outcome in brucellosis
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DOI：
10.1016/j.jinf.2004.10.013
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发表时间：
2005-10-01
影响因子：
28.2
通讯作者：
Bourantas, KL
中科院分区：
文献类型：
--
作者：
Makis, AC;Galanakis, E;Bourantas, KL
目标和方法。布鲁氏菌病的特点是慢性和复发，尽管有效的治疗。细胞因子，尤其是Th 1/Th 2平衡可能参与布鲁氏菌的易感性或耐药性。为了确定治疗结果的预测因素，我们检测了20例布鲁氏菌病患儿治疗前后血清白细胞介素-2（IL-2）和可溶性IL-2受体α（sIL-2 R α）的水平。所有患儿均治疗6周，其中3例（15%）在治疗结束后2、3和8个月复发。治疗前和治疗后的血清IL-2水平在患者和对照组之间没有显著差异。相比之下，患者治疗前sIL-2 R α水平显著升高（P
Objectives and methods. Brucellosis is characterized by chronicity and relapses despite efficacious treatment. Cytokines and especially the Th1/Th2 balance may be involved in the susceptibility or resistance to the Brucella species. In order to identify predictors of treatment outcome, we measured the pre and posttreatment levels of serum interleukin-2 (IL-2) and soluble IL-2 receptor alpha (sIL-2R alpha) in 20 children with brucellosis. All children were treated for 6 weeks and three of them (15%) presented with a relapse at 2, 3 and 8 months after treatment had ended.Results. Serum IL-2 levels, both pretreatment and posttreatment, did not significantly differ between patients and controls. By contrast, pretreatment sIL-2R alpha levels were significantly higher in patients (P