Fusarisolins A-E, Polyketides from the Marine-Derived Fungus Fusarium solani H918
Fusarisolins A-E, Polyketides from the Marine-Derived Fungus Fusarium solani H918
复制标题
Fusarisolins A-E，来自海洋源性真菌 Fusarium solani H918 的聚酮化合物。
DOI：
10.3390/md17020125
复制
发表时间：
2019-02-01
期刊：
影响因子：
5.4
通讯作者：
Yang, Xian-Wen
中科院分区：
文献类型：
--
作者：
Niu, Siwen;Tang, Xi-Xiang;Yang, Xian-Wen
从海洋真菌腐皮镰刀菌H918中分离得到5个新的（镰刀菌素A-E，1 ~ 5）和3个已知的（6 ~ 8）聚酮化合物，沿着6个已知的酚类化合物（9 ~ 14）。通过综合光谱数据分析、甲氧苯乙酸（MPA）法、化学转化法以及与文献报道的数据比较，确定了它们的结构。化合物1和2是前两个天然存在的21个碳聚酮化合物，分别具有稀有的-和-内酯单元。对所有分离物（1 ~ 14）进行了对茶叶病原真菌茶拟盘多毛孢（Pestalotiopsis theae）的抑制作用和3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）合酶基因表达的评价。化合物8显示出有效的抗真菌活性，ED 50值为55 M，而化合物1、8、13和14显著抑制HMG-CoA合酶基因表达。
Five new (fusarisolins A-E, 1 to 5) and three known (6 to 8) polyketides were isolated from the marine-derived fungus Fusarium solani H918, along with six known phenolics (9 to 14). Their structures were established by comprehensive spectroscopic data analyses, methoxyphenylacetic acid (MPA) method, chemical conversion, and by comparison with data reported in the literature. Compounds 1 and 2 are the first two naturally occurring 21 carbons polyketides featuring a rare - and -lactone unit, respectively. All isolates (1 to 14) were evaluated for their inhibitory effects against tea pathogenic fungus Pestalotiopsis theae and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase gene expression. Compound 8 showed potent antifungal activity with an ED50 value of 55 M, while 1, 8, 13, and 14 significantly inhibited HMG-CoA synthase gene expression.