Alkene isomerization/enamide-ene and diene metathesis for the construction of indoles, quinolines, benzofurans and chromenes with a chiral cyclopropane substituent
Alkene isomerization/enamide-ene and diene metathesis for the construction of indoles, quinolines, benzofurans and chromenes with a chiral cyclopropane substituent
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烯烃异构化/烯酰胺-烯和二烯复分解用于构建具有手性环丙烷取代基的吲哚、喹啉、苯并呋喃和色烯
DOI：
10.1039/c0ob00597e
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发表时间：
2011
影响因子：
3.2
通讯作者：
S.
中科院分区：
文献类型：
--
作者：
Kobayashi;T.;Arisawa;M.;Shuto;S.
建立了一种利用末端烯烃异构化和烯-烯或二烯复分解反应合成吲哚、苯并呋喃和2-位带有手性环丙烷的苯并吡喃等双环杂环化合物的方法。该路线也可应用于手性2-环丙基喹啉的合成（顺式和反式）。
A synthetic method for bicyclic heterocycles, such as indole, benzofuran and chromene derivatives bearing a chiral cyclopropane at the 2-position, was established using isomerization of a terminal olefin and enamide-ene or diene metathesis. This route can also be applied to chiral 2-cyclopropylquinoline synthesis (both cis and trans).