Handbook of Polymers for Pharmaceutical Technologies
Handbook of Polymers for Pharmaceutical Technologies
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制药技术聚合物手册
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Felix Meiser
中科院分区：
文献类型：
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作者：
V. Thakur;M. K. Thakur;S. Mangal;I. Larson;Felix Meiser
天然和人造聚合物都广泛用作片剂粘合剂和填充剂粘合剂。聚合物粘合剂的物理化学和机械性能，例如粒径、形状和变形行为是其有效使用的关键。许多此类粘合剂在湿法制粒过程中以溶液形式应用，这有利于其轻松分布，从而提高作为粘合剂的有效性。直接压片和干法制粒被认为是降低工艺复杂性和成本的途径。这些方法需要以干燥形式使用粘合剂，并且可能更难以获得干燥粘合剂在粉末制剂中的均匀分布。因此，需要高比例的这些粘合剂才能产生机械强度高的片剂。在较低比例下，它们通常不足以制造机械强度高的片剂。最近，有人提出了共加工赋形剂生成的创新。共加工是改善赋形剂功能的流行方法，其中两种或多种现有赋形剂通过某种合适的方法组合以产生与组分赋形剂相比具有改进且通常组合的功能的新结构。众所周知，粒径减小可以改善赋形剂的粘合剂性能，但也会使其具有高度内聚性且难以混合。通过颗粒工程，可以定制较小颗粒的表面结构，以优化粉末的内聚-粘附平衡（CAB），从而形成相互作用的混合物。本章回顾了最近在设计表面改性聚合物微辅料结构方面所做的努力，其固有的能力不仅能够有效地形成相互作用的混合物并提供流动增强，而且能够以较低的比例制造更硬的片剂。因此，这种方法代表了一种潜在的新型多功能原型聚合物微赋形剂，用于直接压片和干法制粒工艺。
Both natural and man-made polymers are widely utilized as tablet binders and filler-binders. The physicochemical and mechanical properties such as particle size, shape and deformation behavior of polymeric binders are key in their effective use. Many such binders are applied as solution in a wet granulation process, which facilitate its facile distribution leading to improved effectiveness as a binder. Direct compression and dry granulation are recognized as routes with reduced process complexity and cost. These processes require a binder to be employed in a dry form and it can be more difficult to obtain a homogeneous distribution of a dry binder in a powder formulation. Therefore, these binders are required in high proportions to generate mechanically strong tablets. At lower proportions, they often are insufficient to create mechanically strong tablets. Recently, innovations in the generation of co-processed excipients have been proposed. Co-processing is a popular means of improving excipient functionalities, where two or more existing excipients are combined by some suitable means to generate new structures with improved and often combined functionalities as compared to the component excipients. Particle size reduction is known to improve the binder properties of an excipient, but also makes it highly cohesive and hard to blend. Via particle engineering, surface structure of smaller particles can be tailored to optimize the cohesive-adhesive balance (CAB) of the powder, allowing formation of interactive mixtures. This chapter reviews recent efforts to engineer surface-modified polymeric micro-excipient structures with the inherent ability to not only form an interactive mixture efficiently and provide flow enhancement, but also to create harder tablets at lower proportions. Hence, this approach represents a potential novel multifunctional prototype polymeric micro-excipient for direct compression and dry granulation processes.