Protective effect of shikimic acid on acetic acid induced colitis in rats
Protective effect of shikimic acid on acetic acid induced colitis in rats
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DOI：
10.5897/jmpr11.1748
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发表时间：
2012-03
影响因子：
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通讯作者：
Jianfeng Xing;Jian-ning Sun;Jinyao Sun;Sasa Hu;Chenning Guo;Maoling Wang;Yalin Dong
中科院分区：
文献类型：
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作者：
Jianfeng Xing;Jian-ning Sun;Jinyao Sun;Sasa Hu;Chenning Guo;Maoling Wang;Yalin Dong
本研究旨在探讨从八角茴香中提取的有效成分莽草酸（SA）对醋酸（AA）诱导大鼠结肠炎的作用。雄性Sprague-Dawley大鼠分为对照组、AA组、AA+磺胺吡啶（SASP; 500 mg/kg）组和AA+ SA组，剂量分别为200和400 mg/kg。除对照组外，其余各组均发生结肠炎。AA组给予生理盐水；治疗组分别给予SA或SASP。测定大鼠结肠标本髓过氧化物酶（MPO）、超氧化物歧化酶（SOD）和诱导型一氧化氮合酶（iNOS）的活性以及丙二醛（MDA）和一氧化氮（NO）的水平。本研究结果表明SA对aa性结肠炎的保护作用，可能是由于其抗氧化作用。
The aim of the present study was to investigate the effect of shikimic acid (SA), an active component extracted from Chinese star anise, on acetic acid (AA)-induced colitis in rats. Male Sprague-Dawley rats were divided into five groups: control, AA, AA+sulfasalazine (SASP; 500 mg/kg), and AA + SA at doses of 200 and 400 mg/kg. Colitis was induced in all groups except the control group by AA. The AA group received saline; treatment groups received SA or SASP, respectively. The activities of myeloperoxidase (MPO), superoxide dismutase (SOD) and inducible nitric oxide synthase (iNOS), and the levels of malondialdehyde (MDA) and nitric oxide (NO) were measured from colonic samples. The findings of this study demonstrate the protective effect of SA in AA-induced colitis, probably due to an antioxidant action.
Key words: Shikimic acid, ulcerative colitis, acetic acid, antioxidation.