Extinction and Retrieval + Extinction of Conditioned Fear Differentially Activate Medial Prefrontal Cortex and Amygdala in Rats.
Extinction and Retrieval + Extinction of Conditioned Fear Differentially Activate Medial Prefrontal Cortex and Amygdala in Rats.
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DOI：
10.3389/fnbeh.2015.00369
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发表时间：
2015
影响因子：
3
通讯作者：
Monfils MH
中科院分区：
文献类型：
--
作者：
Lee HJ;Haberman RP;Roquet RF;Monfils MH
将先前中性的条件刺激（CS，如音调）与令人厌恶的非条件刺激（US，如脚震）配对，会导致联想学习，这样，音调本身就会引发条件反应（如冻结）。我们之前已经表明，在再巩固窗口内发生的消退会话（称为检索+消退）减弱了恐惧反应，并防止了巴甫洛夫恐惧条件反射中的恐惧回归（Monfils等人，）。迄今为止，解释标准灭绝和恢复+灭绝之间不同行为结果的机制仍然知之甚少。在这里，我们试图通过Arc catFISH（利用荧光原位杂交（FISH）对时间活动进行细胞室分析）通过这两种方法来检查特定神经系统的差异时间参与。我们的研究结果表明，灭绝和恢复+灭绝导致不同的表达模式，表明它们参与不同的网络。这些发现提供了对啮齿动物在重新巩固过程中允许灭绝以防止恐惧回归的神经机制的深入了解。
Pairing a previously neutral conditioned stimulus (CS; e.g., a tone) to an aversive unconditioned stimulus (US; e.g., a footshock) leads to associative learning such that the tone alone comes to elicit a conditioned response (e.g., freezing). We have previously shown that an extinction session that occurs within the reconsolidation window (termed retrieval + extinction) attenuates fear responding and prevents the return of fear in Pavlovian fear conditioning (Monfils et al.,). To date, the mechanisms that explain the different behavioral outcomes between standard extinction and retrieval + extinction remain poorly understood. Here we sought to examine the differential temporal engagement of specific neural systems by these two approaches using Arc catFISH (cellular compartment analysis of temporal activity using fluorescence in situ hybridization (FISH)). Our results demonstrate that extinction and retrieval + extinction lead to differential patterns of expression, suggesting that they engage different networks. These findings provide insight into the neural mechanisms that allow extinction during reconsolidation to prevent the return of fear in rodents.