Treatment Considerations for Bacterial Vaginosis and the Risk of Recurrence
Treatment Considerations for Bacterial Vaginosis and the Risk of Recurrence
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DOI：
10.1089/jwh.2008.1088
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发表时间：
2009-12-01
影响因子：
3.5
通讯作者：
Beigi, Richard H.
中科院分区：
文献类型：
--
作者：
Chen, Judy Y.;Tian, Haijun;Beigi, Richard H.
背景：细菌性阴道病（BV）的推荐治疗方案具有相似的疗效；因此，治疗的选择应考虑其他因素，如细菌性阴道炎复发的风险和副作用。本研究的目的是调查商业保险人群在接受不同治疗后的阴阴道念珠菌病（VVC）的复发率和获得率。方法：使用2004 ~ 2006年私人行政保险理赔资料。研究对象连续纳入12-50岁的女性，她们服用BV治疗处方（n = 32,268）。采用多因素分析比较四种BV治疗（单剂量克林霉素阴道乳膏（2%）、多剂量克林霉素阴道治疗方案、阴道甲硝唑和口服甲硝唑）治疗后BV和VVC复发率。协变量包括社会人口学和临床特征。结果：总体而言，BV复发率（2.7%）和VVC治疗后（2.9%）较低。接受单剂量克林霉素阴道乳膏（2%）治疗的女性与口服甲硝唑治疗的女性在BV复发的可能性方面没有显著差异。然而，与口服甲硝唑的女性相比，接受其他阴道治疗的女性更有可能经历细菌性阴道炎复发
Background: Recommended regimens for the treatment of bacterial vaginosis (BV) have similar efficacy; thus, the choice of treatment should consider additional factors such as risk of BV recurrence and side effect profile. The purpose of this study was to investigate BV recurrence rates and rates of acquiring vulvovaginal candidiasis (VVC) after different BV treatments in a commercially insured population.Methods: Private administrative insurance claims from 2004 to 2006 were used. Study subjects were continuously enrolled females 12-50 years of age who filled prescriptions for BV treatment (n = 32,268). The four BV treatments (single-dose clindamycin vaginal cream (2%), multiple-dose clindamycin vaginal regimens, vaginal metronidazole, and oral metronidazole) were compared for rates of recurrent BV and VVC after treatment using multivariate analyses. Covariates included sociodemographic and clinical characteristics.Results: Overall, the rate of BV recurrence (2.7%), and VVC posttreatment (2.9%) were low. Women who were treated with single-dose clindamycin vaginal cream (2%) showed no significant difference from women treated with oral metronidazole in the likelihood of BV recurrence. However, women who received other vaginal treatments were significantly more likely to experience BV recurrence compared with women who received oral metronidazole (p