Effect of hyperosmotic solutions on salt excretion and thirst in rats.
Effect of hyperosmotic solutions on salt excretion and thirst in rats.
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高渗溶液对大鼠盐排泄和口渴的影响。
DOI：
10.1152/ajpregu.2000.278.4.r917
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Thunhorst,RL
中科院分区：
文献类型：
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作者：
Schoorlemmer,GH;Johnson,AK;Thunhorst,RL
我们研究了自由活动大鼠输注高渗溶液引起的排尿变化和口渴。颈动脉内输注0.3 M NaCl（4 ml/20 min，在两个颈内动脉之间分开）导致Na+和K+排泄比静脉内输注增加更大，表明头侧传感器参与了对颈动脉内输注的响应。静脉内和颈动脉内输注高渗甘油或尿素（300 mM在150 mM NaCl中）几乎没有影响，表明传感器在血脑屏障（BBB）外。颈动脉内输注高渗甘露醇（300 mM溶于150 mM NaCl）比静脉内输注更有效，表明细胞体积而不是血液中的Na+浓度至关重要。同样，颈动脉内输注（2 ml/20 min，两侧分开），而不是静脉输注高渗NaCl或甘露醇引起口渴。高渗甘油，静脉注射或注入颈动脉，没有引起口渴。我们的结论是，口渴和电解质排泄取决于细胞体积传感器，位于头部，但在血脑屏障外。
We investigated urinary changes and thirst induced by infusion of hyperosmotic solutions in freely moving rats. Intracarotid infusions of 0.3 M NaCl (4 ml/20 min, split between both internal carotid arteries) caused a larger increase in excretion of Na+and K+than intravenous infusions, indicating that cephalic sensors were involved in the response to intracarotid infusions. Intravenous and intracarotid infusions of hyperosmotic glycerol or urea (300 mM in 150 mM NaCl) had little or no effect, suggesting the sensors were outside the blood-brain barrier (BBB). Intracarotid infusion of hypertonic mannitol (300 mM in 150 mM NaCl) was more effective than intravenous infusion, suggesting that cell volume rather than Na+concentration of the blood was critical. Similarly, intracarotid infusion (2 ml/20 min, split between both sides), but not intravenous infusion of hypertonic NaCl or mannitol caused thirst. Hyperosmotic glycerol, infused intravenously or into the carotid arteries, did not cause thirst. We conclude that both thirst and electrolyte excretion depend on a cell volume sensor that is located in the head, but outside the BBB.