Spontaneous HIV controllers might be the key to prevent accelerated immunosenescence of effector CD8+ T cells
Spontaneous HIV controllers might be the key to prevent accelerated immunosenescence of effector CD8+ T cells
复制标题
自发的 HIV 控制者可能是防止效应 CD8 T 细胞加速免疫衰老的关键
DOI：
10.1097/qad.0000000000002343
复制
发表时间：
2019
期刊：
影响因子：
3.8
通讯作者：
Tsukamoto Tetsuo
中科院分区：
文献类型：
--
作者：
Dunbar Paul R.;Cartwright Emily K.;Wein Alexander N.;Tsukamoto Tetsuo;Tiger Li Zheng-Rong;Kumar Nivedha;Uddb?ck Ida E.;Hayward Sarah L.;Ueha Satoshi;Takamura Shiki;Kohlmeier Jacob E.;Tsukamoto Tetsuo
衰老，无论是生理上还是病理上，都会影响艾滋病毒感染者的生活[1]。根据联合国艾滋病毒/艾滋病联合规划署（UNAIDS）的数据，2017年约有3690万人感染艾滋病毒，其中3510万人是成年人[2]。2017年，全球约有94万人死于艾滋病相关疾病，而2004年为190万人，2010年为140万人。这表明艾滋病相关死亡率一直在下降[2]。抗逆转录病毒疗法导致越来越多的艾滋病毒感染者进入老年。2015年，全球580万艾滋病毒感染者年龄超过50岁，约占成年艾滋病毒感染者的17%。在高收入国家，31%的艾滋病毒感染者年龄在50岁以上[3]。艾滋病毒感染者中与艾滋病相关的健康问题比健康个体更常见[4，5]。此外，50岁以下的艾滋病毒感染者可能会加速衰老，并导致负面的健康结果[6]。免疫衰老（即免疫系统的老化）可能会突出这些问题中的一些，并且是一个新兴的研究课题[7]。即使在ART病毒控制良好的个体中，也可能发生全身免疫激活和免疫衰老加速，并导致慢性免疫应答不足
Aging, both physiological and pathological, impacts the lives of people infected with HIV [1]. According to The Joint United Nations Programme on HIV/AIDS (UNAIDS), in 2017, approximately 36.9 million people were living with HIV, of which 35.1 million were adults [2]. Approximately 940000 people died from AIDS-related illness worldwide in 2017, compared with 1.9 million in 2004 and 1.4 million in 2010. This demonstrates that the AIDS-related mortality rate has been decreasing over time [2]. Treatment with antiretroviral therapy (ART) had led to a growing number of HIV-infected individuals entering old age. In 2015, 5.8 million people living with HIV worldwide were aged over 50 years, approximately 17% of the adult population living with HIV. In high-income countries, 31% of people living with HIV were over the age of 50 years [3].Age-related health problems are more common in HIV-infected than healthy individuals [4, 5]. In addition, accelerated aging might occur in HIV-infected patients below the age of 50 years and cause negative health outcomes [6]. Immunosenescence (ie aging of the immune system) may underline some of these problems and is an emerging research topic [7]. Systemic immune activation and the acceleration of immunosenescence may occur even in individuals with good viral control by ARTand cause chronically insufficient immune responses