Extracellular Matrix: Functions in the Nervous System
Extracellular Matrix: Functions in the Nervous System
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DOI：
10.1101/cshperspect.a005108
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发表时间：
2011-01-01
影响因子：
7.2
通讯作者：
Mueller, Ulrich
中科院分区：
文献类型：
--
作者：
Barros, Claudia S.;Franco, Santos J.;Mueller, Ulrich
在发育中和成人的神经系统中，细胞外基质糖蛋白以动态模式表达，数量惊人。神经干细胞、神经元和神经胶质细胞表达介导与特定细胞外基质分子相互作用的受体。体外功能研究和小鼠遗传学研究提供的证据表明，细胞外基质几乎影响神经系统发育和功能的所有方面。在这里，我们将总结最近的发现，这些发现揭示了特定的细胞外基质分子在神经干细胞分化、神经元迁移、轴突束的形成以及周围和中枢神经系统突触的成熟和功能等不同过程中的特定功能。
An astonishing number of extracellular matrix glycoproteins are expressed in dynamic patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia express receptors that mediate interactions with specific extracellular matrix molecules. Functional studies in vitro and genetic studies in mice have provided evidence that the extracellular matrix affects virtually all aspects of nervous system development and function. Here we will summarize recent findings that have shed light on the specific functions of defined extracellular matrix molecules on such diverse processes as neural stem cell differentiation, neuronal migration, the formation of axonal tracts, and the maturation and function of synapses in the peripheral and central nervous system.