Lack of CD 29 (β1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis
Lack of CD 29 (β1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis
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DOI：
10.1016/s0046-8177(00)80223-3
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发表时间：
2000-02-01
期刊：
影响因子：
3.3
通讯作者：
Patriarca, C
中科院分区：
文献类型：
--
作者：
Ponzoni, M;Arrigoni, G;Patriarca, C
血管内淋巴瘤是一种罕见的侵袭性非霍奇金淋巴瘤，其特征是血管腔内肿瘤细胞的生长，通常表现为皮肤或中枢神经系统受累。这种肿瘤选择性血管内生长的机制(S)仍未解释(S)。我们现在报告6例IL手术材料的临床和免疫组织学数据，其中4例进行了尸检。我们的IL病例共有以下特征：(1)B细胞谱系；(2)发病时没有皮肤受累；(3)有侵袭性行为；(4)没有血管外淋巴瘤；此外，1例与胃低级别MALT淋巴瘤相关。我们用免疫组织化学方法研究了福尔马林固定的石蜡包埋切片中与淋巴细胞和内皮细胞黏附现象有关的分子，即CD29(β(1)整合素亚单位)、CD43(白唾液素)、CD44(H-CAM)、CD54(ICAM-1)、胚胎N-GAM(e-NCAM)和EMA(EMA)。在所有病例中，IL聚集物表面均呈CD44阳性反应，但CD29始终呈阴性反应；CD54也缺失。相反，内皮细胞对CD29、CD44和CD54的平均反应性强调了内皮细胞的完整性。鉴于目前认为CD29对淋巴细胞的运输和跨血管的迁移至关重要，而CD54也参与了跨血管的淋巴细胞迁移，我们得出结论，它们在IL中的持续缺失可能有助于其在血管内和播散的分布模式，已知IL与各种常规淋巴瘤的频繁关联；我们的一个病例似乎是IL与低度MALT淋巴瘤相关的第一个报告。版权所有(C)2000，由WE。桑德斯公司。
Intravascular Lymphomatosis (PL) is is rare and usually aggressive form of non-Hodgkin's lymphoma characterized by the growth of neoplastic cells within vascular lumina that usually presents with skin or central nervous system (CNS) involvement. The mechanism(s) for the selective intravascular growth of this neoplasm remain(s) unexplained. We now report clinical and immunohistologic data on surgical material from 6 cases of IL; in 4 of 6 cases, autopsies were performed. Our IL cases shared the following features: (1) B-cell lineage; (2) lack of skin involvement at presentation; (3) aggressive behavior; and (4) lack of extravascular lymphomatous masses; in addition, I case had an associated gastric low-grade MALT lymphoma. We studied by immunohistochemistry formalin-fixed, paraffin-embedded sections with monoclonal antibodies to molecules known to be involved in lymphocyte and endothelial adhesion phenomena, that is, CD29 (beta(1) integrin subunit), CD43 (leukosialin), CD44 (H-CAM), CD54 (ICAM-1), embryonal N-GAM (e-NCAM), and EMA (episialin). In all cases, the surfaces of IL aggregates reacted for CD44 but were consistently negative for CD29; also absent was CD54. Conversely, the integrity of the endothelial cells was underscored by their even reactivity for CD29, CD44, and CD54. Given that CD29 is currently regarded as critical for lymphocyte trafficking in general and for transvascular migration in particular, and CD54 is also involved in transvascular lymphocyte migration, we conclude that their consistent absence in IL may contribute to its intravascular and disseminated distribution pattern, The rather frequent association of IL with various conventional lymphomas is known; pet, one of our cases appears to be the first report of IL associated with a low-grade MALT lymphoma. Copyright (C) 2000 by WE. Saunders Company.