Antifungal Application of Rosin Derivatives from Renewable Pine Resin in Crop Protection.
Antifungal Application of Rosin Derivatives from Renewable Pine Resin in Crop Protection.
复制标题
再生松香衍生物在作物保护中的抗菌应用。
DOI：
10.1021/acs.jafc.0c00562
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发表时间：
2020-03
影响因子：
6.1
通讯作者：
Pan Tao;Chengyu Wu;Jin Hao;Yanqing Gao;Xiaohua He;Jian Li;Shibin Shang;Zhan‐qian Song;Jie Song
中科院分区：
文献类型：
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作者：
Pan Tao;Chengyu Wu;Jin Hao;Yanqing Gao;Xiaohua He;Jian Li;Shibin Shang;Zhan‐qian Song;Jie Song
In the current work, we synthesized two series of dehydroabietyl amide derivatives from natural product rosin and evaluated their antifungal effects on Valsa mali, Phytophthora capsici, Botrytis cinerea, Sclerotinia sclerotiorum and Fusarium oxysporum. In vitro and in vivo antifungal activities results indicated that rosin-based amide compounds containing thiophene heterocycles had better inhibitory effects on B. cinerea. In particular, compound 5b (5-fluoro-2-thiophene dehydroabietyl amide) exhibited the excellent antifungal properties against B. cinerea with EC50 of 0.490 mg/L, which was lower compared to the positive control penthiopyrad (0.562 mg/L). Physiological and biochemical studies showed that the primary action mechanism of compound 5b on B. cinerea changes mycelial morphology, increases cell membrane permeability and inhibits TCA pathway in respiratory metabolism. Furthermore, QSAR and SAR studies revealed that charge distribution of rosin-based amides derivatives have a key role in the antifungal activity through the hydrogen bonding, conjugation and electrostatic interaction between the compounds and the receptors of target. To sum up, this study contributes to the development of rosin-based antifungal agents with novel structure and preferable biological activity.
