Smoking and Hypertension: Independent or Additive Effects to Determining Vascular Damage?
Smoking and Hypertension: Independent or Additive Effects to Determining Vascular Damage?
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DOI：
10.2174/157016111796642706
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发表时间：
2011-09-01
影响因子：
4.5
通讯作者：
Leone, Aurelio
中科院分区：
文献类型：
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作者：
Leone, Aurelio
吸烟与血压升高之间的因果关系尚不清楚。一些观察表明，在吸烟或被动吸烟时，这种情况会短暂增加。晚期稳定期高血压也可能因吸烟而发生。这可能归因于吸烟引发的动脉粥样硬化的进展（如内皮功能障碍）。内皮功能障碍与高血压密切相关。氧化应激导致一氧化氮（NO）可用性受损，导致NO分解，也被认为是另一种机制。吸烟和高血压作为心血管疾病的危险因素似乎具有叠加效应。
A causal relationship between exposure to smoking and increase in blood pressure (BP) is not yet clearly demonstrated. Some observations suggest a transient increase while smoking a cigarette or when exposed to passive smoking. Late stable hypertension may also occur as a consequence of smoking. This could be attributed to the progression of atherogenesis triggered by smoking (e. g. endothelial dysfunction). Endothelial dysfunction is strongly associated with hypertension. Impaired nitric oxide (NO) availability attributable to oxidative stress production, which causes NO break-down, has also been considered as another mechanism. Smoking and hypertension seem to have an additive effect as risk factors for cardiovascular disease.