Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae
Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae
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DOI：
10.4269/ajtmh.2008.78.442
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发表时间：
2008-03-01
影响因子：
3.3
通讯作者：
Sauerwein, Robert W.
中科院分区：
文献类型：
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作者：
Bousema, J. Teun;Drakeley, Chris J.;Sauerwein, Robert W.
恶性疟原虫和疟疾疟原虫是非洲许多地区的地方性疾病。来自疟疾治疗患者的观察表明，与疟疾疟原虫合并感染可能会增加恶性疟原虫配子细胞的产生。我们通过定量核酸序列扩增（quantitative nucleic acid sequencing amplification, QT-NASBA）对肯尼亚单一恶性疟原虫感染或恶性疟原虫和疟疾疟原虫混合感染的儿童进行抗疟治疗后，测定了恶性疟原虫配子细胞的流行率和密度。此外，我们分析了混合物种感染与微观恶性疟原虫配子体流行率之间的关系，这些数据集来自先前发表的研究。在肯尼亚儿童中，混合种感染的QT-NASBA配子体密度增加（P = 0.03）。我们还观察到坦桑尼亚和肯尼亚混合物种感染中恶性疟原虫配子体的显微患病率较高（优势比= 2.15,95%可信区间= 0.99-4.65和2.39,1.58-3.63），但在尼日利亚的一项研究中没有发现。这些数据表明，合并感染疟疾疟原虫与恶性疟原虫配子细胞增多有关。
Plasmodium falciparum and P. malariae occur endemically in many parts of Africa. Observations from malariotherapy patients suggest that co-infection with P. malariae may increase P. falciparum gametocyte production. We determined P. falciparum gametocyte prevalence and density by quantitative nucleic acid sequence-based amplification (QT-NASBA) after antimalarial treatment of Kenyan children with either P. falciparum mono-infection or P. falciparum and P. malariae mixed infection. In addition, we analyzed the relationship between mixed species infections and microscopic P. falciparum gametocyte prevalence in three datasets from previously published studies. In Kenyan children, QT-NASBA gametocyte density was increased in mixed species infections (P = 0.03). We also observed higher microscopic prevalences of P. falciparum gametocytes in mixed species infections in studies from Tanzania and Kenya (odds ratio = 2.15, 95% confidence interval = 0.99-4.65 and 2.39, 1.58-3.63) but not in a study from Nigeria. These data suggest that co-infection with P. malariae is correlated with increased P. falciparum gametocytemia.