Genome duplication, subfunction partitioning, and lineage divergence:: Sox9 in stickleback and zebrafish
Genome duplication, subfunction partitioning, and lineage divergence:: Sox9 in stickleback and zebrafish
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DOI：
10.1002/dvdy.10424
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发表时间：
2003-11-01
影响因子：
2.5
通讯作者：
Postlethwait, JH
中科院分区：
文献类型：
--
作者：
Cresko, WA;Yan, YL;Postlethwait, JH
硬骨鱼类是脊椎动物中物种最丰富的一组，而鳍鱼的基因组复制（四倍化）事件似乎早于生物多样性的显著爆发。鳐鳍鱼基因组复制与硬骨鱼辐射有什么关系？基因组重复可能通过在不同硬骨鱼谱系中的四足动物基因的共同源物之间划分不同的祖先基因子功能而促进谱系分化。为了验证这一假设，我们研究了Sox 9基因重复的棘鱼和斑马鱼，硬骨鱼的谱系分化早期真硬骨鱼进化的基因表达模式。大多数的表达域似乎已经分配之间的Sox 9a和Sox 9 b之前，棘鱼和斑马鱼谱系的分歧，但一些祖先的表达域分布在每个谱系的差异。我们的结论是，一些基因的子功能，所代表的谱系特异性表达域，可能有不同的分类在不同的谱系，这些可能有助于谱系多样化硬骨鱼进化过程中。开发（C）2003 Wiley-Liss，Inc.
Teleosts are the most species-rich group of vertebrates, and a genome duplication (tetraploidization) event in ray-fin fish appears to have preceded this remarkable explosion of biodiversity. What is the relationship of the ray-fin genome duplication to the teleost radiation? Genome duplication may have facilitated lineage divergence by partitioning different ancestral gene subfunctions among co-orthologs of tetrapod genes in different teleost lineages. To test this hypothesis, we investigated gene expression patterns for Sox9 gene duplicates in stickleback and zebrafish, teleosts whose lineages diverged early in Euteleost evolution. Most expression domains appear to have been partitioned between Sox9a and Sox9b before the divergence of stickleback and zebrafish lineages, but some ancestral expression domains were distributed differentially in each lineage. We conclude that some gene subfunctions, as represented by lineage-specific expression domains, may have assorted differently in separate lineages and that these may have contributed to lineage diversification during teleost evolution. Developmental (C) 2003 Wiley-Liss, Inc.