Hemiparetic muscle atrophy and increased intramuscular fat in stroke patients
Hemiparetic muscle atrophy and increased intramuscular fat in stroke patients
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DOI：
10.1053/apmr.2002.36399
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发表时间：
2002-12-01
影响因子：
4.3
通讯作者：
Macko, RF
中科院分区：
文献类型：
--
作者：
Ryan, AS;Dobrovolny, CL;Macko, RF
目的：探讨慢性（bbb60mo）偏瘫脑卒中患者的偏瘫肢体是否存在骨骼肌萎缩和肌肉内脂肪沉积增多的现象。设计：横断面研究。环境：医院研究中心。参与者：60例患者（男性47例，女性13例，平均年龄标准差65±9y）。干预措施：不适用。主要观察指标：患者通过双能x线吸收仪进行全身扫描，以确定体脂百分比、总瘦质量、脂肪质量、麻痹和未受影响的腿、大腿和手臂的瘦质量。30名患者接受了大腿中部的计算机断层扫描（CT），以确定肌肉面积、皮下脂肪和低密度瘦组织，作为肌肉面积内脂肪的测量，麻痹和未受影响的大腿中部。结果：患者身体状况良好（Vo(2)Peak: 1.2+/-0.3L/rnin），体脂率31.4%+/-9.8%，总瘦质量51.4+/-9.1 kg。瘫腿和大腿的瘦质量分别比未受影响的腿低4%和3% (P
Objective: To determine if skeletal muscle atrophy and greater fat deposition within the muscle are present in the hemiparetic limb of chronic (>6mo) hemiparetic stroke patients.Design: Cross-sectional study.Setting: Hospital-based research center.Participants: Sixty patients (47 men, 13 women; mean age standard deviation, 65 +/- 9y). Interventions: Not applicable.Main Outcome Measures: Patients underwent a total body scan by dual-energy x-ray absorptiometry to determine percentage of body fat, total lean mass, fat mass, and lean mass of the paretic and nonaffected legs, thighs, and arms. Thirty patients received computed tomography (CT) scans of their midthigh to determine muscle area, subcutaneous fat, and low-density lean tissue, as a measure of fat within the muscle area, of the paretic and nonaffected midthigh.Results: Patients were deconditioned (Vo(2)Peak: 1.2+/-0.3L/rnin) with a percentage of body fat of 31.4%+/-9.8% and total lean mass of 51.4+/-9.1 kg. Lean mass of the paretic leg and thigh were 4% and 3% lower than the nonaffected leg (P