MicroRNAs in Bone Balance and Osteoporosis
MicroRNAs in Bone Balance and Osteoporosis
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DOI：
10.1002/ddr.21260
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发表时间：
2015-08-01
影响因子：
3.8
通讯作者：
Dong, Shiwu
中科院分区：
文献类型：
--
作者：
Chen, Junying;Qiu, Min;Dong, Shiwu
骨是一个刚性和动态的器官，经历不断更新。骨稳态通过破骨细胞介导的骨吸收和成骨细胞介导的骨形成来维持。这种平衡的中断可能会导致各种疾病，包括骨质疏松症，这是一个公共卫生问题，因为髋部骨折的发生率很高，而髋部骨折是骨质疏松症最严重的后果。骨质疏松症中的骨丢失是由于骨吸收相对于骨形成的增加。因此，成骨细胞和破骨细胞活性的调节是骨质疏松症治疗的主要焦点。microRNA（miRNAs）是一类由18-22个核苷酸组成的单链非编码RNA，其在细胞分化、细胞命运、凋亡和各种疾病状态的发病机制中具有重要作用。miRNAs在骨疾病治疗中的潜在治疗和生物标志物功能正受到越来越多的关注。本文综述了miRNAs在细胞水平上对骨功能的作用及其治疗潜力。药物开发研究76：235-245，2015年。(c)2015 Wiley Periodicals，Inc.
Bone is a rigid and dynamic organ that undergoes continuous turnover. Bone homeostasis is maintained by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The interruption of this balance can cause various diseases, including osteoporosis a public health issue due to the rate of hip fracture, the most serious outcome of osteoporosis. The bone loss in osteoporosis results from an increase in bone resorption versus bone formation. Thus, regulation of osteoblast and osteoclast activity is a main focus in the treatment of osteoporosis. MicroRNAs (miRNAs) are a class of single stranded noncoding RNAs consisting of 18-22 nucleotides that have an important role in cell differentiation, cell fate, apoptosis, and pathogenesis in various disease states. The potential therapeutic and biomarker function of miRNAs in treating bone disorders is receiving more attention. The current review summarizes the role of miRNAs in bone function at a cellular level in the context of their therapeutic potential. Drug Dev Res 76 : 235-245, 2015. (c) 2015 Wiley Periodicals, Inc.